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首页> 外文期刊>Infection and immunity >Invasion and Multiplication of Helicobacter pylori in Gastric Epithelial Cells and Implications for Antibiotic Resistance
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Invasion and Multiplication of Helicobacter pylori in Gastric Epithelial Cells and Implications for Antibiotic Resistance

机译：幽门螺杆菌在胃上皮细胞中的侵袭和繁殖及其对抗生素耐药性的影响

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摘要

Helicobacter pylori is a Gram-negative, spiral-shaped bacterium that infects more than 50% of the human population and can cause gastritis, peptic ulcer, or gastric malignancies. It is generally viewed as an extracellular microorganism. In a gentamicin protection assay on AGS or MKN45 cells, H. pylori could invade the epithelial cells and multiply within double-layer vesicles either on the plasma membrane or in the cytoplasm. A 5-fold increase in the number of bacteria was recultured from the infected cells at 12 h, compared with the number of invading cells at 2.5 h postinfection. The autophagic vesicles induced by H. pylori are the sites of replication and also of the degradation of the replicating bacteria after fusion with lysosomes. Many H. pylori bacteria in coccoid form associated with the plasma membrane can be released into culture. Only cell-penetrating antibiotics can enhance the intracellular killing of the replicating bacteria. The multiplication of H. pylori within cells provides a niche for its resistance to antibacterial therapy and has a significant impact on its biological life cycle.
机译：幽门螺杆菌是革兰氏阴性螺旋状细菌，感染超过50％的人口，可引起胃炎，消化性溃疡或胃恶性肿瘤。通常将其视为细胞外微生物。在针对AGS或MKN45细胞的庆大霉素保护试验中， H。幽门螺杆菌可侵袭上皮细胞并在质膜或细胞质的双层囊泡中繁殖。与感染后2.5小时的侵袭细胞数相比，在12小时时从感染的细胞中培养出细菌数增加了5倍。由 H诱导的自噬囊泡。幽门螺杆菌是溶酶体融合后的复制位点，也是复制细菌的降解位点。许多 H。与质膜结合的类球体形式的幽门螺杆菌可以被释放到培养物中。只有穿透细胞的抗生素才能增强复制细菌的细胞内杀伤力。 H的乘法。细胞内的幽门螺杆菌为其抗细菌治疗提供了利基，并对其生物学生命周期产生了重大影响。

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