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首页> 外文期刊>Infection and immunity >Mycobacterium bovis BCG-Specific Th17 Cells Confer Partial Protection against Mycobacterium tuberculosis Infection in the Absence of Gamma Interferon
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Mycobacterium bovis BCG-Specific Th17 Cells Confer Partial Protection against Mycobacterium tuberculosis Infection in the Absence of Gamma Interferon

机译：在没有γ干扰素的情况下，牛分枝杆菌BCG特异的Th17细胞对结核分枝杆菌感染具有部分保护作用

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Protective immunity against tuberculosis (TB) requires the integrated response of a network of lymphocytes. Both gamma interferon (IFN-γ)- and interleukin 17 (IL-17)-secreting CD4+ T cells have been identified in subjects with latent TB infection and during experimental Mycobacterium tuberculosis infection, but the contribution of Th17 cells to protective immunity is unclear. To examine their protective effects in vivo, we transferred mycobacterium-specific IL-17- and IFN-γ-secreting CD4+ T cells isolated from M. tuberculosis BCG-immunized IL-12p40?/? and IFN-γ?/? or wild-type mice, respectively, into M. tuberculosis-infected IL-12p40?/? or RAG?/? mice. In the absence of IL-12 and IL-23, neither IL-17-secreting (Th17) nor IFN-γ-secreting (Th1) BCG-specific T cells expanded or provided protection against M. tuberculosis. In RAG?/? recipients with an intact IL-12/IL-23 axis, both Th17 and Th1 cells were activated and induced significant protection against M. tuberculosis. The reduction in the bacterial load following transfer of IFN-γ?/? Th17 cells was associated with significant prolongation of survival compared to recipients of na?ve IFN-γ?/? T cells. This effect was at the cost of an increased inflammatory infiltrate characterized by an excess of neutrophils. Therefore, Th17 cells can provide IFN-γ-independent protection against M. tuberculosis, and this effect may contribute to the early control of M. tuberculosis infection.
机译：对结核病（TB）的保护性免疫需要淋巴细胞网络的整合反应。 γ干扰素（IFN-γ）和白介素17（IL-17）分泌的CD4 + T细胞已在潜在的TB感染受试者和实验性结核分枝杆菌感染期间被鉴定出，但Th17细胞对保护性免疫的贡献尚不清楚。为了检查它们在体内的保护作用，我们转移了分离自结核分枝杆菌BCG免疫的IL-12p40α/β的分泌分枝杆菌特异性IL-17和IFN-γ的CD4 + T细胞。和IFN-γ？或野生型小鼠分别感染结核分枝杆菌感染的IL-12p40α/β。还是RAG？/？老鼠。在没有IL-12和IL-23的情况下，IL-17分泌（Th17）和IFN-γ分泌（Th1）BCG特异性T细胞均未扩增或提供抗结核分枝杆菌的保护。在RAG中？/？ IL-12 / IL-23轴完整的受者，Th17和Th1细胞均被激活并诱导出针对结核分枝杆菌的显着保护作用。转移IFN-γ/α后细菌载量的减少。与单纯的IFN-γ/β受体相比，Th17细胞的存活期显着延长。 T细胞。这种作用是以增加嗜中性白细胞为特征的炎性浸润的代价为代价的。因此，Th17细胞可以提供不依赖IFN-γ的结核分枝杆菌保护，这种作用可能有助于早期控制结核分枝杆菌感染。

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