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首页> 外文期刊>Infection and immunity >Caenorhabditis elegans Immune Conditioning with the Probiotic Bacterium Lactobacillus acidophilus Strain NCFM Enhances Gram-Positive Immune Responses
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Caenorhabditis elegans Immune Conditioning with the Probiotic Bacterium Lactobacillus acidophilus Strain NCFM Enhances Gram-Positive Immune Responses

机译：秀丽隐杆线虫的免疫调节与益生菌嗜酸乳杆菌菌株NCFM增强了革兰氏阳性免疫反应。

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Although the immune response of Caenorhabditis elegans to microbial infections is well established, very little is known about the effects of health-promoting probiotic bacteria on evolutionarily conserved C. elegans host responses. We found that the probiotic Gram-positive bacterium Lactobacillus acidophilus NCFM is not harmful to C. elegans and that L. acidophilus NCFM is unable to colonize the C. elegans intestine. Conditioning with L. acidophilus NCFM significantly decreased the burden of a subsequent Enterococcus faecalis infection in the nematode intestine and prolonged the survival of nematodes exposed to pathogenic strains of E. faecalis and Staphylococcus aureus, including multidrug-resistant (MDR) isolates. Preexposure of nematodes to Bacillus subtilis did not provide any beneficial effects. Importantly, L. acidophilus NCFM activates key immune signaling pathways involved in C. elegans defenses against Gram-positive bacteria, including the p38 mitogen-activated protein kinase pathway (via TIR-1 and PMK-1) and the β-catenin signaling pathway (via BAR-1). Interestingly, conditioning with L. acidophilus NCFM had a minimal effect on Gram-negative infection with Pseudomonas aeruginosa or Salmonella enterica serovar Typhimurium and had no or a negative effect on defense genes associated with Gram-negative pathogens or general stress. In conclusion, we describe a new system for the study of probiotic immune agents and our findings demonstrate that probiotic conditioning with L. acidophilus NCFM modulates specific C. elegans immunity traits.
机译：尽管秀丽隐杆线虫对微生物感染的免疫反应已得到充分确立，但对于增进健康的益生菌对进化上保守的秀丽隐杆线虫宿主反应的影响知之甚少。我们发现益生菌革兰氏阳性菌嗜酸乳杆菌NCFM对秀丽隐杆线虫无害，嗜酸乳杆菌NCFM不能在秀丽隐杆线虫肠中定植。用嗜酸乳杆菌NCFM进行调理可显着降低线虫肠中随后的粪肠球菌感染的负担，并延长暴露于粪肠球菌和金黄色葡萄球菌病原菌株（包括耐多药（MDR）分离株）的线虫的存活时间。线虫预先暴露于枯草芽孢杆菌并没有提供任何有益效果。重要的是，嗜酸乳杆菌NCFM激活了秀丽隐杆线虫对革兰氏阳性细菌防御相关的关键免疫信号通路，包括p38丝裂原激活的蛋白激酶通路（通过TIR-1和PMK-1）和β-catenin信号通路（通过BAR-1）。有趣的是，用嗜酸乳杆菌NCFM调理对铜绿假单胞菌或肠炎沙门氏菌鼠伤寒沙门氏菌的革兰氏阴性感染影响最小，对与革兰氏阴性病原体或一般压力有关的防御基因没有影响或有负面影响。总之，我们描述了一种用于研究益生菌免疫剂的新系统，我们的发现表明，用嗜酸乳杆菌NCFM进行益生菌调节可调节秀丽隐杆线虫的免疫性状。

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