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首页> 外文期刊>Infection and immunity >Innate Immune Responses and Modified Extracellular Matrix Regulation Characterize Bacterial Infection and Cellular/Connective Tissue Changes in Scarring Trachoma
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Innate Immune Responses and Modified Extracellular Matrix Regulation Characterize Bacterial Infection and Cellular/Connective Tissue Changes in Scarring Trachoma

机译：先天性免疫反应和修改后的细胞外基质调节表征瘢痕性沙眼的细菌感染和细胞/结缔组织变化。

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Trachoma is the most common infectious cause of blindness and a major public health problem in many developing countries. It is caused by recurrent ocular infection with Chlamydia trachomatis in childhood, with conjunctival scarring seen later in life. The pathogenesis of trachomatous scarring, however, is poorly understood, and this study was carried out to investigate the immunofibrogenic correlates of trachomatous conjunctival scarring. A case-control study of 363 cases with conjunctival scarring and 363 control participants was conducted. Investigations included in vivo confocal microscopy (IVCM) assessment, quantitative real-time PCR gene expression, C. trachomatis detection, and nonchlamydial bacterial culture. Trachomatous scarring was found to be strongly associated with a proinflammatory, innate immune response with increased expression of psoriasin, interleukin-1β, tumor necrosis factor alpha, defensin-β4A, chemokine ligand 5, and serum amyloid A1. There was also differential expression of various modifiers of the extracellular matrix, including metalloproteinases 7, 9, 10, and 12, tissue inhibitor of matrix metalloproteinase 1, and secreted protein acidic cystein-rich-like 1. The expression of many of these genes was also significantly associated with the presence of nonchlamydial bacterial infection. These infections had a marked effect on conjunctival immune processes, including an increased inflammatory infiltrate and edema seen with IVCM. This study supports the possibility that the immunofibrogenic response in scarring trachoma is partly stimulated by nonchlamydial bacterial infection, which is characterized by the expression of innate factors.
机译：在许多发展中国家，沙眼是致盲的最常见传染原因，也是主要的公共卫生问题。它是由儿童时期沙眼衣原体的反复眼部感染引起的，在以后的生活中见到结膜瘢痕。然而，人们对沙眼结膜瘢痕的发病机理了解甚少，因此本研究旨在研究沙眼结膜瘢痕的免疫纤维化相关性。进行了363例结膜瘢痕病例和363例对照参与者的病例对照研究。研究包括体内共聚焦显微镜（IVCM）评估，定量实时PCR基因表达，沙眼衣原体检测和非衣原体细菌培养。发现沙眼性瘢痕与促炎性先天免疫反应密切相关，并伴有psoriasin，白介素-1β，肿瘤坏死因子α，防御素-β4A，趋化因子配体5和血清淀粉样蛋白A1表达增加。细胞外基质的各种修饰物也有差异表达，包括金属蛋白酶7、9、10和12，基质金属蛋白酶1的组织抑制剂，以及分泌的酸性酸性半胱氨酸样蛋白1。许多这些基因的表达是也与非衣原体细菌感染的存在显着相关。这些感染对结膜免疫过程有显着影响，包括IVCM所见的炎性浸润和水肿增加。这项研究支持瘢痕性沙眼的免疫纤维化反应部分受到非衣原体细菌感染的刺激，其特征在于先天因子的表达。

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