Bgp, a Secreted Glycosaminoglycan-Binding Protein of Borrelia burgdorferi Strain N40, Displays Nucleosidase Activity and Is Not Essential for Infection of Immunodeficient Mice

Nikhat Parveen; Kenneth A. Cornell; James L. Bono; Christen Chamberland; Patricia Rosa; John M. Leong

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Bgp, a Secreted Glycosaminoglycan-Binding Protein of Borrelia burgdorferi Strain N40, Displays Nucleosidase Activity and Is Not Essential for Infection of Immunodeficient Mice

机译：Bgp，伯氏疏螺旋体N40的一种分泌的糖胺聚糖结合蛋白，显示核糖核酸酶活性，对于免疫缺陷小鼠不是必需的。

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Bgp, one of the surface-localized glycosaminoglycan-binding proteins of the Lyme disease spirochete, Borrelia burgdorferi, exhibited nucleosidase activity. Infection of SCID mice with B. burgdorferi strain N40 mutants harboring a targeted insertion in bgp and apparently retaining all endogenous plasmids revealed that Bgp is not essential for colonization of immunocompromised mice.

机译：Bgp是莱姆病螺旋体 Borrelia burgdorferi 的一种表面定位的糖胺聚糖结合蛋白，具有核苷酶活性。 SCID小鼠感染 B。 burgdorferi N40突变株在 bgp 中有针对性地插入，并且显然保留了所有内源性质粒，这表明Bgp对于免疫受损小鼠的定殖不是必需的。 展开▼

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《Infection and immunity》 |2006年第5期|共5页

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Nikhat Parveen; Kenneth A. Cornell; James L. Bono; Christen Chamberland; Patricia Rosa; John M. Leong;
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中图分类医学免疫学;

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1. Borrelia burgdorferi Population Dynamics and Prototype Gene Expression during Infection of Immunocompetent and Immunodeficient Mice [J] . Emir Hodzic, Sunlian Feng, Kim J. Freet, Infection and immunity . 2003,第9期

机译：免疫能力强和免疫缺陷小鼠感染期间伯氏疏螺旋体的种群动态和原型基因表达。

2. Protective efficacy of an oral vaccine to reduce carriage of Borrelia burgdorferi (strain N40) in mouse and tick reservoirs [J] . Scheckelhoff MR, Telford SR, Hu LT Vaccine . 2006,第11期

机译：口服疫苗对减少小鼠和壁虱贮藏中伯氏疏螺旋体（菌株N40）的运输的保护作用

3. The dbpBA Locus of Borrelia burgdorferi Is Not Essential for Infection of Mice [J] . Yanlin Shi, Qilong Xu, Sunita V. Seemanapalli, Infection and immunity . 2006,第11期

机译：伯氏疏螺旋体的dbpBA基因座对于小鼠感染不是必需的

4. Characterization of Borrelia burgdorferi proteins associated with mammalian infection. [D] . Miller, Jennifer Caruso. 2003

机译：与哺乳动物感染相关的伯氏疏螺旋体蛋白的表征。

5. Bgp a Secreted Glycosaminoglycan-Binding Protein of Borrelia burgdorferi Strain N40 Displays Nucleosidase Activity and Is Not Essential for Infection of Immunodeficient Mice [O] . Nikhat Parveen, Kenneth A. Cornell, James L. Bono, 2006

机译：Bgp伯氏疏螺旋体N40的一种分泌的糖胺聚糖结合蛋白显示核酸酶活性对于免疫缺陷小鼠不是必需的。

6. Bgp, a Secreted Glycosaminoglycan-Binding Protein of Borrelia burgdorferi Strain N40, Displays Nucleosidase Activity and Is Not Essential for Infection of Immunodeficient Mice† [O] . Parveen, Nikhat, Cornell, Kenneth A., Bono, James L., 2006

机译：Bgp是疏螺旋体伯氏疏螺旋体N40株的一种分泌型糖胺聚糖结合蛋白，具有核酸酶活性，对于免疫缺陷小鼠并非必需†

7. Macrophages in Resistance to Rickettsial Infection: Strains of Mice Susceptible to the Lethal Effects of Rickettsia akari Show Defective Macrophage Rickettsicidal Activity in vitro [R] . Nacy, C. A., Meltzer, M. S. 1981

机译：抗立克次体感染的巨噬细胞：易受立克次体致死效应影响的小鼠品系显示体外缺陷巨噬细胞立克次体活性

1. Borrelia burgdorferi immunologically active proteins, test kits containing these proteins and suitable for detecting antibodies in test liquids, monoclonal antibodies directed against the immunologically active proteins and the use of these proteins as vaccines against infections caused by Borrelia strains [P] . 外国专利： DE4018988C2 . 1999-07-08

机译：伯氏疏螺旋体具有免疫活性的蛋白质，包含这些蛋白质的检测试剂盒以及适用于检测检测液体中的抗体的试剂盒，针对具有免疫活性的蛋白质的单克隆抗体以及将这些蛋白质用作抵抗由疏螺旋体菌株引起的感染的疫苗的用途

2. IMMUNOLOGICALLY ACTIVE PROTEINS FROM BORRELIA BURGDORFERI, RELATED TEST KITS WHICH CONTAIN THESE PROTEINS AND ARE SUITABLE FOR DETECTING ANTIBODIES IN TEST FLUIDS, AND THE USE OF THESE PROTEINS AS VACCINES AGAINST INFECTIONS CAUSED BY BORRELIA STRAINS [P] . 外国专利： CA2072008C . 2003-01-28

机译：伯氏疏螺旋体，包含这些蛋白且适合检测测试液中抗原的相关测试试剂盒的免疫活性蛋白，以及将这些蛋白用作疫苗以预防葡萄球菌引起的感染

3. IMMUNOLOGICALLY ACTIVE PROTEINS FROM BORRELIA BURGDORFERI, RELATED TEST KITS WHICH CONTAIN THESE PROTEINS AND ARE SUITABLE FOR DETECTING ANTIBODIES IN TEST FLUIDS, AND THE USE OF THESE PROTEINS AS VACCINES AGAINST INFECTIONS CAUSED BY BORRELIA STRAINS [P] . 外国专利： CA2072008A1 . 1991-06-23

机译：伯氏疏螺旋体的免疫活性蛋白，相关的测试试剂盒包含这些蛋白，并且适合检测测试液中的抗体，以及将这些蛋白用作疫苗以预防葡萄球菌引起的感染

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Bgp, a Secreted Glycosaminoglycan-Binding Protein of Borrelia burgdorferi Strain N40, Displays Nucleosidase Activity and Is Not Essential for Infection of Immunodeficient Mice

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