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首页> 外文期刊>Infection and immunity >Displacement of Pathogens by an Engineered Bacterium Is a Multifactorial Process That Depends on Attachment Competition and Interspecific Antagonism
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Displacement of Pathogens by an Engineered Bacterium Is a Multifactorial Process That Depends on Attachment Competition and Interspecific Antagonism

机译：工程菌置换病原体是一个多因素过程，取决于依附竞争和种间拮抗作用。

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Pathogen attachment to host cells is a key process during infection, and inhibition of pathogen adhesion is a promising approach to the prevention of infectious disease. We have previously shown that multivalent adhesion molecules (MAMs) are abundant in both pathogenic and commensal bacterial species, mediate early attachment to host cells, and can contribute to virulence. Here, we investigated the efficacy of an engineered bacterium expressing a commensal MAM on its surface in preventing pathogen attachment and pathogen-mediated cytotoxicity in a tissue culture infection model. We were able to dissect the individual contributions of adhesion and interspecific antagonism on the overall outcome of infection for a range of different pathogens by comparison with the results obtained with a fully synthetic adhesion inhibitor. We found that the potential of the engineered bacterium to outcompete the pathogen is not always solely dependent on its ability to hinder host attachment but, depending on the pathogenic species, may also include elements of interspecific antagonism, such as competition for nutrients and its ability to cause a loss of fitness due to production of antimicrobial factors.
机译：病原体与宿主细胞的附着是感染过程中的关键过程，抑制病原体粘附是预防感染性疾病的有前途的方法。先前我们已经表明，多价粘附分子（MAM）在致病菌和共生细菌种类中均很丰富，可以介导早期附着于宿主细胞，并且可以提高毒性。在这里，我们调查了一种在其表面表达共生MAM的工程菌在组织培养感染模型中预防病原体附着和病原体介导的细胞毒性的功效。通过与使用完全合成的黏附抑制剂获得的结果进行比较，我们能够剖析黏附和种间拮抗作用对感染的总体结果的个体贡献。我们发现，工程细菌胜过病原体的潜力并不总是仅取决于其阻碍宿主附着的能力，而是取决于病原体，还可能包括种间拮抗作用的要素，例如竞争性养分及其对细菌的抵抗能力。由于产生抗菌素而导致身体不适。

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