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首页> 外文期刊>Infection and immunity >TREM-1 Signaling Promotes Host Defense during the Early Stage of Infection with Highly Pathogenic Streptococcus suis
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TREM-1 Signaling Promotes Host Defense during the Early Stage of Infection with Highly Pathogenic Streptococcus suis

机译：TREM-1信号在感染高致病性猪链球菌感染的早期促进宿主防御

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摘要

Infection with highly pathogenic Streptococcus suis can cause septic shock, which is characterized by high levels of inflammatory cytokines and a high mortality rate. Our previous study indicated that TREM-1 (triggering receptor expressed on myeloid cells 1) was upregulated in swine spleen cells in response to S. suis infection. The role of TREM-1 signaling in enhancement of the proinflammatory response promoted us to examine its effect on the outcome of S. suis infection. In the present study, the recombinant extracellular domain of TREM-1 (rTREM-1) and an agonistic TREM-1 antibody were used to inhibit and activate TREM-1 signaling to evaluate its role in neutrophil activation, pathogen clearance, proinflammatory cytokine response, and the outcome of highly pathogenic S. suis infection in a mouse model. Blockage of TREM-1 signaling caused a more severe proinflammatory response to S. suis infection and increased the mortality rate, while its activation had the opposite effect. Blockage or activation of TREM-1 signaling lowered or raised the number of neutrophils in the blood, which correlated well with host clearance of S. suis. In conclusion, the TREM-1-mediated innate immune response played an essential role in the activation of neutrophils and S. suis clearance, which further reduced severe inflammation and finally benefited the outcome of the infection.
机译：高致病性猪链球菌感染可引起败血性休克，其特征是高水平的炎症细胞因子和高死亡率。我们以前的研究表明，猪脾细胞中的TREM-1（在髓样细胞1上表达的触发受体）被猪链球菌感染上调。 TREM-1信号在增强促炎反应中的作用促使我们研究其对猪链球菌感染结果的影响。在本研究中，TREM-1的重组胞外域（rTREM-1）和激动性TREM-1抗体被用来抑制和激活TREM-1信号传导，以评估其在嗜中性粒细胞活化，病原体清除，促炎细胞因子反应，和高致病性猪链球菌感染在小鼠模型中的结果。 TREM-1信号的阻滞导致对猪链球菌感染的更严重的促炎反应并增加了死亡率，而其激活却具有相反的作用。 TREM-1信号的阻断或激活降低或增加了血液中嗜中性粒细胞的数量，这与猪链球菌的宿主清除率密切相关。总之，TREM-1介导的先天免疫应答在嗜中性粒细胞和猪链球菌清除中起着至关重要的作用，这进一步减轻了严重的炎症反应，并最终使感染的结果受益。

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