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首页> 外文期刊>Infection and immunity >The Collagen Binding Protein Cnm Contributes to Oral Colonization and Cariogenicity of Streptococcus mutans OMZ175
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The Collagen Binding Protein Cnm Contributes to Oral Colonization and Cariogenicity of Streptococcus mutans OMZ175

机译：胶原蛋白结合蛋白Cnm有助于变形链球菌OMZ175的口腔定植和致龋性

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Streptococcus mutans is the etiological agent of dental caries and one of the many bacterial species implicated in infective endocarditis. The expression of the collagen-binding protein Cnm by S. mutans has been associated with extraoral infections, but its relevance for dental caries has only been theorized to date. Due to the collagenous composition of dentinal and root tissues, we hypothesized that Cnm may facilitate the colonization of these surfaces, thereby enhancing the pathogenic potential of S. mutans in advancing carious lesions. As shown for extraoral endothelial cell lines, Cnm mediates the invasion of oral keratinocytes and fibroblasts by S. mutans. In this study, we show that in the Cnm+ native strain, OMZ175, Cnm mediates stringent adhesion to dentinal and root tissues as well as collagen-coated surfaces and promotes both cariogenicity and carriage in vivo. In vitro, ex vivo, and in vivo experiments revealed that while Cnm is not universally required for S. mutans cariogenicity, it contributes to (i) the invasion of the oral epithelium, (ii) enhanced binding on collagenous surfaces, (iii) implantation of oral biofilms, and (IV) the severity of caries due to a native Cnm+ isolate. Taken together, our findings reveal that Cnm is a colonization factor that contributes to the pathogenicity of certain S. mutans strains in their native habitat, the oral cavity.
机译：变形链球菌是龋齿的病因，也是许多与感染性心内膜炎有关的细菌之一。变形链球菌的胶原结合蛋白Cnm的表达与口腔外感染有关，但是到目前为止，它与龋齿的相关性还没有被理论化。由于牙本质和牙根组织的胶原蛋白组成，我们假设Cnm可能促进这些表面的定殖，从而增强变形链球菌在推进龋齿病变中的致病潜力。如口腔外内皮细胞系所示，Cnm介导变形链球菌侵袭口腔角质形成细胞和成纤维细胞。在这项研究中，我们表明，在Cnm + 天然菌株OMZ175中，Cnm介导了对牙本质和根组织以及胶原蛋白涂层表面的严格粘附，并在体内促进了致癌性和运输性。体外，离体和体内实验表明，变形链球菌致癌性并非普遍需要Cnm，但它有助于（i）入侵（ii）增强胶原表面上的结合力;（iii）植入口腔生物膜;（IV）由于天然Cnm + 分离株而引起的龋齿严重程度。综上所述，我们的发现表明Cnm是一种定殖因子，有助于某些变形链球菌菌株在其自然栖息地（口腔）中的致病性。

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