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首页> 外文期刊>International Journal of Molecular Sciences >New Dihydro-β-agarofuran Sesquiterpenes from Parnassia wightiana Wall: Isolation, Identification and Cytotoxicity against Cancer Cells
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New Dihydro-β-agarofuran Sesquiterpenes from Parnassia wightiana Wall: Isolation, Identification and Cytotoxicity against Cancer Cells

机译：来自帕纳斯氏菌壁的新型二氢-β-琼脂呋喃倍半萜烯：针对癌细胞的分离，鉴定和细胞毒性

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摘要

Five new (4–8) and three known (1–3) dihydro-β-agarofuran sesquiterpene polyesters were isolated from the whole plants of Parnassia wightiana. The structures of all compounds were elucidated through spectroscopic analysis including 2D-NMR and HR-MS. The absolute configuration of these compounds was established by X-ray diffraction analysis, comparison of NOESY spectra and biogenetic means. The cytotoxities of compounds 2–8 were evaluated in vitro against HL-60, SMMC-7721, A549, MCF-7 and SW480 cell lines. Compounds 5–7 exhibited the highest activities with IC50 values of 11.8–30.1 μM in most cases. The SAR revealed that the introduction of hydroxyl group was able to significantly improve the activities of the compounds for most of the cell lines.
机译：从百日草的整个植物中分离出五种新的（4-8）和三种已知的（1-3）二氢-β-agarofuran倍半萜烯聚酯。通过包括2D-NMR和HR-MS在内的光谱分析阐明了所有化合物的结构。这些化合物的绝对构型是通过X射线衍射分析，NOESY光谱和生物遗传手段的比较而确定的。在体外评估了化合物2-8对HL-60，SMMC-7721，A549，MCF-7和SW480细胞系的细胞毒性。在大多数情况下，化合物5-7表现出最高的活性，IC 50 值为11.8-30.1μM。 SAR显示，引入羟基能够显着提高大多数细胞系化合物的活性。

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