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首页> 外文期刊>International Journal of Molecular Sciences >Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection
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Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection

机译：使用蛋白质组学了解利什曼原虫寄生虫如何在宿主体内存活并建立感染

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Leishmania is a protozoan parasite that causes a wide range of different clinical manifestations in mammalian hosts. It is a major public health risk on different continents and represents one of the most important neglected diseases. Due to the high toxicity of the drugs currently used, and in the light of increasing drug resistance, there is a critical need to develop new drugs and vaccines to control Leishmania infection. Over the past few years, proteomics has become an important tool to understand the underlying biology of Leishmania parasites and host interaction. The large-scale study of proteins, both in parasites and within the host in response to infection, can accelerate the discovery of new therapeutic targets. By studying the proteomes of host cells and tissues infected with Leishmania , as well as changes in protein profiles among promastigotes and amastigotes, scientists hope to better understand the biology involved in the parasite survival and the host-parasite interaction. This review demonstrates the feasibility of proteomics as an approach to identify new proteins involved in Leishmania differentiation and intracellular survival.
机译：利什曼原虫是一种原生动物寄生虫，在哺乳动物宿主中引起多种不同的临床表现。它是不同大陆的主要公共卫生风险，是最重要的被忽视疾病之一。由于当前使用的药物的高毒性，并且鉴于耐药性增加，因此迫切需要开发新的药物和疫苗来控制利什曼原虫感染。在过去的几年中，蛋白质组学已成为了解利什曼原虫寄生虫的生物学原理和宿主相互作用的重要工具。应对寄生虫和宿主体内感染的蛋白质进行大规模研究，可以加快新治疗靶标的发现。通过研究被利什曼原虫感染的宿主细胞和组织的蛋白质组，以及前鞭毛体和变形虫中蛋白质谱的变化，科学家希望更好地了解与寄生虫存活和宿主-寄生虫相互作用有关的生物学。这篇综述证明了蛋白质组学作为一种鉴定与利什曼原虫分化和细胞内存活有关的新蛋白质的方法的可行性。

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