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Evaluation of Mycobacterium tuberculosis -specific antibody responses for the discrimination of active and latent tuberculosis infection

机译：评价结核分枝杆菌特异性抗体应答以区分活动性和潜伏性结核感染

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Objectives The serological antibody detection tests offer several advantages for the rapid diagnosis of tuberculosis (TB). The Mycobacterium tuberculosis -specific antibody responses associated with different stages of TB infection remain to be investigated. Methods The Pathozyme-Myco IgG (Myco G), Pathozyme TB Complex Plus (TB Complex), IBL M. tuberculosis IgG ELISA (IBL), Anda Biologicals TB IgG (Anda-TB), and T-SPOT. TB (T-SPOT) tests were performed for 133 active TB patients (ATB group), 131 controls (CON group), and 95 subjects with latent TB infection (LTBI group). Results The four serological tests all showed relatively low sensitivity in the ATB group but high specificity in the LTBI and CON groups. The antibody levels of the four serological tests were significantly higher in the ATB group than in the LTBI group. The same trend was observed between the LTBI and CON groups. The four serological tests demonstrated potential diagnostic value in discriminating ATB from LTBI. A combination of the Anda-TB and TB Complex tests exhibited the best diagnostic potential in discriminating ATB from LTBI, with a sensitivity of 89.4% and a specificity of 94.7%. Further, the diagnostic value of Anda-TB and TB Complex were validated in a prospective cohort including 106 patients with suspected ATB. Combined with the T-SPOT test, the tests showed a sensitivity of 87.2% and a specificity of 92.5% for discriminating ATB patients from all ATB suspected cases in the validation group. Conclusions The antibody responses of the serological tests all showed significant differences between the ATB and LTBI groups. A combination of Anda-TB and the TB Complex test demonstrated high diagnostic potential in discriminating ATB from LTBI and may be an additional diagnostic tool in the diagnosis of M. tuberculosis infection.
机译：目的血清学抗体检测测试为快速诊断结核病（TB）提供了多个优势。与结核感染的不同阶段相关的结核分枝杆菌特异性抗体应答仍有待研究。方法病原酶-Myco IgG（Myco G），病原菌TB Complex Plus（TB Complex），IBL结核分枝杆菌IgG ELISA（IBL），Anda Biologics TB IgG（Anda-TB）和T-SPOT。对133例活动性TB患者（ATB组），131例对照（CON组）和95例潜在的TB感染（LTBI组）进行了TB（T-SPOT）测试。结果四种血清学检测均显示ATB组的敏感性较低，而LTBI和CON组的特异性较高。 ATB组的四种血清学检测的抗体水平显着高于LTBI组。在LTBI和CON组之间观察到了相同的趋势。四种血清学检测证明了将ATB与LTBI鉴别的潜在诊断价值。 Anda-TB和TB Complex测试的组合在区分ATB和LTBI方面显示出最佳的诊断潜力，灵敏度为89.4％，特异性为94.7％。此外，在包括106名疑似ATB患者的前瞻性队列中验证了Anda-TB和TB Complex的诊断价值。与T-SPOT测试相结合，该测试显示，在验证组中，将ATB患者与所有ATB可疑病例区分开来的敏感性为87.2％，特异性为92.5％。结论血清学检测的抗体反应均显示ATB组和LTBI组之间存在显着差异。 Anda-TB和TB Complex测试的组合显示出将ATB与LTBI区分的高诊断潜力，并且可能是诊断结核分枝杆菌感染的另一种诊断工具。

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