• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International journal of infectious diseases : >Investigation of the risk factors associated with the failure of hepatitis B vaccination of neonates in Yunnan province, China
【24h】

Investigation of the risk factors associated with the failure of hepatitis B vaccination of neonates in Yunnan province, China

机译：云南省新生儿乙肝疫苗接种失败相关危险因素调查

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective This study aimed to investigate HBsAg positive rates and risk factors of HBV infection among the children less than 15 years old in Yunnan province, a remote southwest part of mainland China. Methods Multi-stage sampling was used to randomly select study subjects from 9,360,000 individuals. Hepatitis B vaccine inoculation rate and HBsAg positive rate were investigated, and then propensity score and generalized linear mixed model (GLMMs) were applied to the case-control study. Results The average HBsAg positive rate was 1.81%, with 1.2% in urban areas and 2.4% in rural areas. Rate of first-dose-in-time in urban areas was 77.7%, obviously higher than 49.5% in rural areas ( χ 2 = 2811.71, P 0.01). Similarly, 3-dose completion coverage rate in urban areas was 93.7%, also higher than 79.0% in rural areas ( χ 2 = 1561.43, P 0.01). Maternal HBeAg positivity and HBsAg positivity were proved to be the main risk factors of children with HBV infection. Moreover, paternal HBeAg positivity, paternal HBsAg positivity, the absence and unknown status of HBV vaccine inoculation were risk factors of children with HBV infection as well. Conclusion It was very important to improve the HBV vaccine inoculation rates. Delivering babies in hospital and timely inoculation with HBV vaccine were efficient ways to prevent HBV vertical transmission.
机译：目的研究中国大陆偏远的云南省15岁以下儿童的HBsAg阳性率和HBV感染危险因素。方法采用多阶段抽样从936万名受试者中随机选择研究对象。调查乙型肝炎疫苗接种率和HBsAg阳性率，然后将倾向评分和广义线性混合模型（GLMMs）应用于病例对照研究。结果平均HBsAg阳性率为1.81％，城市地区为1.2％，农村地区为2.4％。城镇首次服药率为77.7％，明显高于农村地区的49.5％（χ2 = 2811.71，P <0.01）。同样，城市地区的三剂完成率达93.7％，也高于农村地区的79.0％（χ2 = 1561.43，P <0.01）。孕妇HBeAg阳性和HBsAg阳性被证明是儿童HBV感染的主要危险因素。此外，父亲HBeAg阳性，父亲HBsAg阳性，HBV疫苗接种的不存在和未知状况也是患HBV感染儿童的危险因素。结论提高HBV疫苗接种率非常重要。分娩婴儿和及时接种HBV疫苗是预防HBV垂直传播的有效方法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号