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首页> 外文期刊>International Journal of Molecular Sciences >Chemical Composition and in Vitro Antifungal Activity Screening of the Allium ursinum L. (Liliaceae)
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Chemical Composition and in Vitro Antifungal Activity Screening of the Allium ursinum L. (Liliaceae)

机译：欧亚葱（百合科）的化学组成和体外抗真菌活性筛选

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The objective of the study was to summarize the methods for isolating and identifying natural sulfur compounds from Allium ursinum (ramson) and to discuss the active constituents with regard to antifungal action. Using chromatographic techniques, the active constituents were isolated and subsequently identified. Analyses by high-performance liquid chromatography (HPLC) suggested that these compounds were sulfur constituents, with a characteristic absorbance at 250 nm. Gas chromatography-mass spectrometry (GC-MS) analyses allowed the chemical structures of the isolated constituents to be postulated. We adopted the same methods to identify the health-giving profiling of ramsons and the effects are thought to be primarily derived from the presence and breakdown of the alk(en)ylcysteine sulphoxide, alliin and its subsequent breakdown to allicin (sulfur-compounds of ramson) in connection with antifungal action. The aim of the study was the characterization of the chemical composition of ramsons and the testing of the action of the in vitro extracts, on different strains of Candida albicans. The main goal was to highlight the most efficient extracts of Allium ursinum that can provide long-term antifungal activity without remissions. The extracts from Allium ursinum plants, inhibited growth of Candida spp. cells at concentrations ranging from 0.5 to 4.0 mg/mL, while that of adherent cells at concentrations ranging from 1.0 to 4.0 mg/mL, depending on the yeast and plant species.
机译：这项研究的目的是概述从乌头葱（ramson）中分离和鉴定天然硫化合物的方法，并讨论与抗真菌作用有关的活性成分。使用色谱技术，分离出活性成分，然后进行鉴定。高效液相色谱（HPLC）分析表明，这些化合物为硫成分，在250 nm处具有特征吸收。气相色谱-质谱（GC-MS）分析允许假定分离出的成分的化学结构。我们采用了相同的方法来确定Ramson的健康状况，其作用被认为主要源自烷基（烯）基半胱氨酸亚砜，蒜氨酸的存在和分解，以及随后分解为大蒜素（ramson的硫化合物） ）与抗真菌作用有关。该研究的目的是表征Ramsons的化学成分，并测试体外提取物对白色念珠菌菌株的作用。主要目标是突出最有效的乌葱提取物，该提取物可提供长期的抗真菌活性，且不会缓解。葱属植物的提取物抑制了念珠菌的生长。取决于酵母和植物种类，浓度为0.5至4.0 mg / mL的贴壁细胞，而浓度为1.0至> 4.0 mg / mL的贴壁细胞。

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