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首页> 外文期刊>International journal of infectious diseases : >Immune profiling of the progression of a BALB/c mouse aerosol infection by Burkholderia pseudomallei and the therapeutic implications of targeting HMGB1
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Immune profiling of the progression of a BALB/c mouse aerosol infection by Burkholderia pseudomallei and the therapeutic implications of targeting HMGB1

机译：假性伯克霍尔德菌对BALB / c小鼠气溶胶感染进程的免疫学分析及靶向HMGB1的治疗意义

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Introduction: The role of damage-associated molecular pattern HMGB1 signalling in a murine BALB/c model of severe respiratory melioidosis (Burkholderia pseudomallei infection) was explored in this study. Methods: Time course experiments were performed. Results: It was established that HMGB1 was released in concert with increasing weight of organs and increasing concentration of liver enzymes in the blood a short time after cytokine release. Differences in the cytokine response between organs were observed, where the lungs contained higher concentrations of chemokines and interleukin 17, while the spleen produced more interferon-gamma, which is essential in the host defence against B. pseudomallei. This is evidence as to why the disease is seemingly more severe in the respiratory form. The effect of depleting HMGB1 using an antibody was also evaluated. It was found that this treatment significantly reduced bacterial load in the liver, spleen, and, to a greater degree, in the lungs. Cytokine quantification indicated that this reduction in bacterial load is likely due to the treatment reducing the release of a variety of pro-inflammatory cytokines. Conclusion: It is concluded that anti-HMGB1 treatment would be effective alongside other therapeutics, where it would reduce the characteristic over-inflammation associated with late stage infection.
机译：简介：本研究探讨了与损伤相关的分子模式HMGB1信号在鼠BALB / c模型中的作用，该模型在小鼠严重呼吸性类鼻osis病（伯克霍尔德菌假性马来酸感染）中具有重要作用。方法：进行时程实验。结果：已确定HMGB1在细胞因子释放后的短时间内与器官重量增加和血液中肝酶浓度增加协同释放。观察到器官之间细胞因子反应的差异，其中肺中含有较高浓度的趋化因子和白介素17，而脾脏产生更多的干扰素-γ，这在抵抗假苹果芽孢杆菌的宿主防御中至关重要。这是为什么这种疾病似乎在呼吸形式上更为严重的证据。还评估了使用抗体消耗HMGB1的效果。发现该治疗显着降低了肝脏，脾脏以及更大程度地肺中的细菌负荷。细胞因子的定量表明，这种细菌载量的减少可能是由于减少了多种促炎性细胞因子释放的治疗所致。结论：结论：抗HMGB1疗法与其他疗法有效，可减少与晚期感染有关的特征性过度炎症。

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