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首页> 外文期刊>International journal of infectious diseases : >An association study of NRAMP1, VDR, MBL and their interaction with the susceptibility to tuberculosis in a Chinese population
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An association study of NRAMP1, VDR, MBL and their interaction with the susceptibility to tuberculosis in a Chinese population

机译：NRAMP1，VDR，MBL及其与中国人群结核病易感性的关联研究

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Objectives: To investigate natural-resistance-associated macrophage protein 1 (NRAMP1), mannose-binding lectin (MBL), vitamin D receptor (VDR) gene polymorphisms and their interaction with susceptibility to pulmonary tuberculosis (PTB) in a Chinese population. Methods: A case-control study was conducted in PTB (n=151), age- and sex- matched healthy controls (HCs) (n=453). Genetic polymorphisms of NRAMP1 (INT4, D543NA and 3'UTR), MBL (HL, PQ, XY and AB) and VDR (FokI and Taq) were analyzed by using PCR-restriction fragment length polymorphism (RFLP) and PCR- single- strand conformation polymorphism (SSCP) techniques. Multifactor dimensionality reduction (MDR) analysis was carried out to assess the effects of the interaction between SNPs. Results: The distribution of NRAMP1- 3'UTR (TGTG/del), MBL- HL (H/L) and FokI (F/f) were significantly different between PTB patients and HCs (p<0.05). HPYA (OR: 1.88; 95% CI: 1.22-2.91), LPXA (OR: 3.17; 95% CI: 1.69- 5.96), LQYA (OR: 3.52; 95%CI: 1.50-8.23) and LPYB (OR: 12.37; 95%CI: 3.75- 40.85) of MBL were risk haplotypes for PTB. The TGTG- H- f (OR: 1.70; 95%CI: 1.10-2.62) and del- H-f (OR: 3.48; 95% CI: 1.45-8.37) of 3'UTR- HL- FokI were also high-risk haplotypes associated with tuberculosis. Conclusions: Our study suggests that genotypes of many polymorphic genes are associated with TB, it is necessary to further explore the mechanism of genotypes and gene-gene interaction in susceptibility to tuberculosis.
机译：目的：研究中国人群中与自然抗性相关的巨噬细胞蛋白1（NRAMP1），甘露糖结合凝集素（MBL），维生素D受体（VDR）基因多态性及其与肺结核易感性的相互作用。方法：在PTB（n = 151），年龄和性别匹配的健康对照（HCs）（n = 453）中进行了病例对照研究。使用PCR限制性片段长度多态性（RFLP）和PCR单链分析了NRAMP1（INT4，D543NA和3'UTR），MBL（HL，PQ，XY和AB）和VDR（FokI和Taq）的遗传多态性。构象多态性（SSCP）技术。进行了多维度降维（MDR）分析，以评估SNP之间相互作用的影响。结果：PTB患者和HCs之间的NRAMP1-3'UTR（TGTG / del），MBL-HL（H / L）和FokI（F / f）的分布有显着差异（p <0.05）。 HPYA（OR：1.88; 95％CI：1.22-2.91），LPXA（OR：3.17; 95％CI：1.69-5.96），LQYA（OR：3.52; 95％CI：1.50-8.23）和LPYB（OR：12.37） ; 95％CI：3.75-40.85）MBL是PTB的危险单倍型。 3'UTR-HL-FokI的TGTG-H-f（OR：1.70; 95％CI：1.10-2.62）和del-Hf（OR：3.48; 95％CI：1.45-8.37）也是高风险单倍型与结核有关。结论：我们的研究表明，许多多态性基因的基因型与结核病有关，有必要进一步探讨基因型和基因-基因相互作用对结核病易感性的机制。

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