Mechanism of Sphingosine 1-Phosphate- and Lysophosphatidic Acid-Induced Up-Regulation of Adhesion Molecules and Eosinophil Chemoattractant in Nerve Cells

Gerald Gleich; Marie-Therese Walsh; Mazin Atiyeh; Michael Maloney; Richard W. Costello

首页> 外文期刊>International Journal of Molecular Sciences >Mechanism of Sphingosine 1-Phosphate- and Lysophosphatidic Acid-Induced Up-Regulation of Adhesion Molecules and Eosinophil Chemoattractant in Nerve Cells

【24h】

Mechanism of Sphingosine 1-Phosphate- and Lysophosphatidic Acid-Induced Up-Regulation of Adhesion Molecules and Eosinophil Chemoattractant in Nerve Cells

机译：鞘氨醇1-磷酸和溶血磷脂酸诱导神经细胞黏附分子和嗜酸性粒细胞趋化因子上调的机制

获取原文

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The lysophospholipids sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA) act via G-protein coupled receptors S1P_1–5 and LPA_1–3 respectively, and are implicated in allergy. Eosinophils accumulate at innervating cholinergic nerves in asthma and adhere to nerve cells via intercellular adhesion molecule-1 (ICAM-1). IMR-32 neuroblastoma cells were used as an in vitro cholinergic nerve cell model. The G_i coupled receptors S1P₁, S1P₃, LPA₁, LPA₂ and LPA₃ were expressed on IMR-32 cells. Both S1P and LPA induced ERK phosphorylation and ERK- and G_i-dependent up-regulation of ICAM-1 expression, with differing time courses. LPA also induced ERK- and G_i-dependent up-regulation of the eosinophil chemoattractant, CCL-26. The eosinophil granule protein eosinophil peroxidase (EPO) induced ERK-dependent up-regulation of transcription of S1P₁, LPA₁, LPA₂ and LPA₃, providing the situation whereby eosinophil granule proteins may enhance S1P- and/or LPA- induced eosinophil accumulation at nerve cells in allergic conditions.

机译：溶血磷脂1-磷酸鞘氨醇（S1P）和溶血磷脂酸（LPA）分别通过G蛋白偶联受体S1P _{1-5 和LPA _{1-3 发挥作用。在过敏。嗜酸性粒细胞聚集在支配哮喘的胆碱能神经中，并通过细胞间粘附分子-1（ICAM-1）粘附至神经细胞。 IMR-32神经母细胞瘤细胞用作体外胆碱能神经细胞模型。 G _{i 偶联受体S1P _{1 ，S1P _{3 ，LPA _{1 ，LPA _{2 和LPA _{3 在IMR-32细胞上表达。 S1P和LPA均可诱导ERK磷酸化以及ERK和G _{i 依赖的ICAM-1表达的上调，但时间有所不同。 LPA还诱导嗜酸性粒细胞趋化因子CCL-26的ERK和G _{i 依赖性上调。嗜酸性粒细胞蛋白嗜酸性粒细胞过氧化物酶（EPO）诱导ERK依赖性上调S1P _{1 ，LPA _{1 ，LPA _{2 和LPA的转录_{3 ，提供了这样一种情况：嗜酸性粒细胞颗粒蛋白可能在过敏条件下增强S1P和/或LPA诱导的嗜酸性粒细胞在神经细胞的蓄积。}}}}}}}}}}}}}}

著录项

来源
《International Journal of Molecular Sciences》 |2011年第5期|共13页
作者
Gerald Gleich; Marie-Therese Walsh; Mazin Atiyeh; Michael Maloney; Richard W. Costello;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种
中图分类生物物理学;
关键词

相似文献

外文文献
中文文献
专利

1. Mechanisms of hyaluronan-induced up-regulation of ICAM-1 and VCAM-1 expression by murine kidney tubular epithelial cells: hyaluronan triggers cell adhesion molecule expression through a mechanism involving activation of nuclear factor-kappa B and act [J] . Oertli B, Beck-Schimmer B, Fan X, The Journal of Immunology: Official Journal of the American Association of Immunologists . 1998,第7期

机译：透明质酸诱导的鼠肾小管上皮细胞ICAM-1和VCAM-1表达上调的机制：透明质酸通过涉及核因子-κB激活的机制触发细胞粘附分子表达
2. Hypothermic preservation of lung allograft inhibits cytokine-induced chemoattractant-1, endothelial leucocyte adhesion molecule, vascular cell adhesion molecule-1 and intracellular adhesion molecule-1 expression. [J] . Hanusch C, Nowak K, Gill IS, Clinical and Experimental Immunology: An Official Journal of the British Society for Immunology . 2007,第2期

机译：低温保存肺同种异体移植物可抑制细胞因子诱导的chemoattractant-1，内皮白细胞粘附分子，血管细胞粘附分子-1和细胞内粘附分子1的表达。
3. Intercellular Cell Adhesion Molecule-1, Vascular Cell Adhesion Molecule-1, and Regulated on Activation Normal T Cell Expressed and Secreted Are Expressed by Human Breast Carcinoma Cells and Support Eosinophil Adhesion and Activation [J] . Shahina Ali, Jaswinder Kaur, Kamala D. Patel American Journal of Pathology . 2000,第1期

机译：细胞间粘附分子-1，血管细胞粘附分子1，并受激活的调节正常的T细胞表达和分泌是由人类乳腺癌细胞表达并支持嗜酸性粒细胞的粘附和激活。
4. Using optical tweezers to examine the chemotactic force to a single inflammatory cell—eosinophil stimulated by chemoattractants prepared from Toxocara Canis larvae [C] . Po-Chen Shih, Yi-Jr Su, Ke-Min Chen, Optical Trapping and Optical Micromanipulation II . 2005

机译：使用光镊检查对单个炎性细胞的化学趋化力-嗜酸性粒细胞是由弓形虫Toxocara Canis幼虫制备的趋化因子刺激的
5. Signal transduction mechanisms regulating the activation, adhesion and migration of human eosinophils and T-lymphocytes in allergic inflammation. [D] . Ip, Wai Ki. 2003

机译：信号转导机制调节变应性炎症中人类嗜酸性粒细胞和T淋巴细胞的活化，粘附和迁移。
6. Mechanism of Sphingosine 1-Phosphate- and Lysophosphatidic Acid-Induced Up-Regulation of Adhesion Molecules and Eosinophil Chemoattractant in Nerve Cells [O] . Richard W. Costello, Michael Maloney, Mazin Atiyeh, 2011

机译：鞘氨醇1-磷酸和溶血磷脂酸诱导神经细胞黏附分子和嗜酸性粒细胞趋化因子上调的机制
7. Mechanism of sphingosine 1-phosphate- and lysophosphatidic Acid-induced up-regulation of adhesion molecules and eosinophil chemoattractant in nerve cells. [O] . Costello, Richard W, Maloney, Michael, Atiyeh, Mazin, 2012

机译：1-磷酸鞘氨醇和溶血磷脂酸诱导神经细胞黏附分子和嗜酸性粒细胞趋化剂上调的机制。
8. Eosinophil Cell Lines in a Tri-Cell Multicellular Tumor Spheroid (MTS)/Endothelium Complex: Down Regulation of Adhesion and Integrin Molecules- Implications of Metastasis Inhibition [R] . Furbert-Harris, P. M. 2003

机译：三细胞多细胞肿瘤球体（mTs）/内皮复合物中的嗜酸性粒细胞系：粘附和整合素分子的下调 - 转移抑制的意义

Mechanism of Sphingosine 1-Phosphate- and Lysophosphatidic Acid-Induced Up-Regulation of Adhesion Molecules and Eosinophil Chemoattractant in Nerve Cells

摘要

著录项

相似文献

相关主题

期刊订阅