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首页> 外文期刊>International Journal of Molecular Sciences >d-(+)-Galactose-Conjugated Single-Walled Carbon Nanotubes as New Chemical Probes for Electrochemical Biosensors for the Cancer Marker Galectin-3
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d-(+)-Galactose-Conjugated Single-Walled Carbon Nanotubes as New Chemical Probes for Electrochemical Biosensors for the Cancer Marker Galectin-3

机译:d-(+)-半乳糖共轭单壁碳纳米管作为癌症标记物Galectin-3电化学生物传感器的新化学探针。

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d-(+)-Galactose-conjugated single-walled carbon nanotubes (SWCNTs) were synthesized for use as biosensors to detect the cancer marker galectin-3. To investigate the binding of galectin-3 to the d-(+)-galactose-conjugated SWCNTs, an electrochemical biosensor was fabricated by using molybdenum electrodes. The binding affinities of the conjugated SWCNTs to galectin-3 were quantified using electrochemical sensitivity measurements based on the differences in resistance together with typical I-V characterization. The electrochemical sensitivity measurements of the d-(+)-galactose-conjugated SWCNTs differed significantly between the samples with and without galectin-3. This indicates that d-(+)-galactose-conjugated SWCNTs are potentially useful electrochemical biosensors for the detection of cancer marker galectin-3.
机译:合成了d-(+)-半乳糖共轭单壁碳纳米管(SWCNT),用作生物传感器来检测癌症标记物Galectin-3。为了研究galectin-3与d-(+)-半乳糖共轭的SWCNT的结合,通过使用钼电极制备了电化学生物传感器。使用基于电阻差异的电化学敏感性测量以及典型的I-V表征,可以量化结合的SWCNT与Galectin-3的结合亲和力。有和没有galectin-3的样品之间,d-(+)-半乳糖共轭的SWCNT的电化学灵敏度测量结果有显着差异。这表明d-(+)-半乳糖共轭的SWCNTs是潜在有用的电化学生物传感器,用于检测癌症标志物galectin-3。

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