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首页> 外文期刊>International Journal of Molecular Sciences >Quantification and Application of Potential Epigenetic Markers in Maternal Plasma of Pregnancies with Hypertensive Disorders
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Quantification and Application of Potential Epigenetic Markers in Maternal Plasma of Pregnancies with Hypertensive Disorders

机译：高血压病孕妇血浆中潜在表观遗传标记的定量应用

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The aim of this study was to evaluate quantitative aberrations of novel fetal-specific epigenetic markers in maternal plasma of pregnancies with hypertensive disorders. We compared the concentrations of DSCR3, RASSF1A, and SRY as cell-free fetal DNA markers in 188 normal pregnancies, 16 pregnancies with early-onset preeclampsia (EO-PE), 47 pregnancies with late-onset preeclampsia (LO-PE), and 29 pregnancies with gestational hypertension (GH). The concentrations of all markers were significantly correlated with gestational age (p 0.001 for all). Strong positive correlations were also observed between DSCR3 and SRY (r = 0.471, p 0.001), as well as between RASSF1A and SRY (r = 0.326, p = 0.015) and between DSCR3 and RASSF1A (r = 0.673, p 0.001). The concentrations of DSCR3 and RASSF1A in the EO-PE were significantly higher at 24–32 weeks and onwards (p 0.05 for both). In the LO-PE, DSCR3 and RASSF1A concentrations were significantly higher only at 33–41 weeks compared with the controls. The concentrations of all markers in the GH group were not significantly different from those in the control group. This study is the first demonstration that DSCR3 is a novel epigenetic marker that can be an alternative to the RASSF1A for the prediction of EO-PE.
机译：这项研究的目的是评估妊高征孕妇血浆中新的胎儿特异性表观遗传标记的定量畸变。我们比较了188例正常妊娠，16例早发先兆子痫（EO-PE），47例早发先兆子痫（LO-PE）和DSCR3，RASSF1A和SRY作为无细胞胎儿DNA标记的浓度。 29例妊娠合并妊娠高血压（GH）。所有标志物的浓度均与胎龄显着相关（所有p <0.001）。在DSCR3和SRY之间（r = 0.471，p <0.001），RASSF1A和SRY之间（r = 0.326，p = 0.015）以及DSCR3和RASSF1A之间（r = 0.673，p <0.001）也观察到强正相关。 。在24-32周及以后，EO-PE中DSCR3和RASSF1A的浓度显着升高（两者均p <0.05）。在LO-PE中，与对照组相比，仅在33-41周时DSCR3和RASSF1A的浓度显着较高。 GH组中所有标志物的浓度与对照组无显着差异。这项研究是第一个证明DSCR3是新型表观遗传标记，可以替代RASSF1A预测EO-PE。

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