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首页> 外文期刊>International Journal of Molecular Sciences >Composition, Cytotoxic and Antimicrobial Activities of Satureja intermedia C.A.Mey Essential Oil
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Composition, Cytotoxic and Antimicrobial Activities of Satureja intermedia C.A.Mey Essential Oil

机译：中间沙门氏菌C.A. Mey精油的组成，细胞毒性和抗菌活性

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摘要

In this study, the essential oil (EO) constituents from the aerial parts of Satureja intermedia C.A.Mey were detected by GC and GC/MS. The antimicrobial activity of EO on oral pathogens and its cytotoxicity to human cancer cells were determined by the microbroth dilution method and the crystal violet staining method, respectively. Thirty-nine compounds were identified and the main EO constituents were γ-terpinene (37.1%), thymol (30.2%), p-cymene (16.2%), limonene (3.9%), α-terpinene (3.3%), myrcene (2.5%), germacrene B (1.4%), elemicine (1.1%) and carvacrol (0.5%). The S. intermedia EO showed a concentration-dependent decrease in viability of Hep-G2 (hepatocellular carcinoma) and MCF-7 (breast adenocarcinoma) human cancer cell lines (p 0.05). Antimicrobial screening of S. intermedia EO demonstrated slight antibacterial and antifungal activities against Streptococcus mutants, S. salivarius, Enterococcus faecalis, Staphylococcus aureus, Candida albicans and C. glabrata. Further preclinical studies are needed to assess the efficacy and safety of S. intermedia EO as a new promising anticancer agent.
机译：在这项研究中，通过GC和GC / MS检测了来自Satureja intermedia C.A. Mey地上部分的精油（EO）成分。分别通过微肉汤稀释法和结晶紫染色法测定了EO对口腔病原体的抗菌活性及其对人癌细胞的细胞毒性。鉴定出39种化合物，主要EO成分为γ-萜品烯（37.1％），百里酚（30.2％），对伞花烯（16.2％）、,烯（3.9％），α-萜品烯（3.3％），月桂烯（ 2.5％），胚ac B（1.4％），艾美霉素（1.1％）和香芹酚（0.5％）。中间链球菌EO显示出Hep-G2（肝细胞癌）和MCF-7（乳腺腺癌）人癌细胞系存活率的浓度依赖性降低（p <0.05）。中间链球菌EO的抗菌素筛选显示对链球菌突变体，唾液链球菌，粪肠球菌，金黄色葡萄球菌，白色念珠菌和光滑念珠菌有轻微的抗菌和抗真菌活性。需要进一步的临床前研究来评估中间链球菌EO作为一种新的有前景的抗癌药的疗效和安全性。

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