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首页> 外文期刊>International Journal of Molecular Sciences >Preparation of a Paeonol-Containing Temperature-Sensitive In Situ Gel and Its Preliminary Efficacy on Allergic Rhinitis
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Preparation of a Paeonol-Containing Temperature-Sensitive In Situ Gel and Its Preliminary Efficacy on Allergic Rhinitis

机译：含丹皮酚的温度敏感原位凝胶的制备及其对变应性鼻炎的初步疗效

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摘要

In this paper, the optimal composition of a paeonol temperature-sensitive in situ gel composed of poloxamer 407 (P407) was determined, and a preliminary study of its effect on allergic rhinitis was performed. The optimal composition of the paeonol temperature-sensitive in situ gel included 2% paeonol inclusion, 22% P407, 2% poloxamer 188 (P188) and 2% PEG6000, as assessed by thermodynamic and rheological studies. The toad palate model was employed to study the toxicity of the paeonol temperature-sensitive in situ gel on the nasal mucosa. The result of this experiment showed low toxicity to cilia, which allows the gel to be used for nasal administration. The Franz diffusion cell method was used to study the in vitro release of paeonol and suggested that the in vitro release was in line with the Higuchi equation. This result suggests that the paeonol could be absorbed into the body through mucous membranes and had some characteristics of a sustained effect. Finally, the guinea pig model of ovalbumin sensitized allergic rhinitis was used to evaluate the preliminary efficacy of the gel, with the paeonol temperature-sensitive in situ gel showing a significant effect on the guinea pig model of sensitized allergic rhinitis (AR).
机译：本文确定了由泊洛沙姆407（P407）组成的丹皮酚温度敏感型原位凝胶的最佳组成，并对它对变应性鼻炎的影响进行了初步研究。通过热力学和流变学研究评估，丹皮酚对温度敏感的原位凝胶的最佳组成包括2％丹皮酚夹杂物，22％P407、2％泊洛沙姆188（P188）和2％PEG6000。蟾蜍pa模型用于研究丹皮酚温度敏感的原位凝胶对鼻黏膜的毒性。该实验的结果表明对纤毛的毒性低，这使得该凝胶可用于鼻腔给药。用Franz扩散池法研究了丹皮酚的体外释放，并认为该体外释放符合Higuchi方程。该结果表明丹皮酚可以通过粘膜吸收到体内，并具有一些持续作用的特征。最后，卵白蛋白致敏性鼻炎的豚鼠模型用于评估凝胶的初步功效，丹皮酚温度敏感原位凝胶对敏化性过敏性鼻炎（AR）的豚鼠模型显示出显著作用。

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