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首页> 外文期刊>International Journal of Molecular Sciences >Naringin Enhances CaMKII Activity and Improves Long-Term Memory in a Mouse Model of Alzheimer’s Disease
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Naringin Enhances CaMKII Activity and Improves Long-Term Memory in a Mouse Model of Alzheimer’s Disease

机译：柚皮苷增强阿尔茨海默氏病小鼠模型中的CaMKII活性并改善长期记忆

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The Amyloid-β (Aβ)-induced impairment of hippocampal synaptic plasticity is an underlying mechanism of memory loss in the early stages of Alzheimer’s disease (AD) in human and mouse models. The inhibition of the calcium/calmodulin-dependent protein kinase II (CaMKII) autophosphorylation plays an important role in long-term memory. In this study, we isolated naringin from Pomelo peel (a Citrus species) and studied its effect on long-term memory in the APPswe/PS1dE9 transgenic mouse model of AD. Three-month-old APPswe/PS1dE9 transgenic mice were randomly assigned to a vehicle group, two naringin (either 50 or 100 mg/kg body weight/day) groups, or an Aricept (2 mg/kg body weight/day) group. After 16 weeks of treatment, we observed that treatment with naringin (100 mg/kg body weight/day) enhanced the autophosphorylation of CaMKII, increased the phosphorylation of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic (AMPA) receptor at a CaMKII-dependent site and improved long-term learning and memory ability. These findings suggest that the increase in CaMKII activity may be one of the mechanisms by which naringin improves long-term cognitive function in the APPswe/PS1dE9 transgenic mouse model of AD.
机译：淀粉样β（Aβ）诱导的海马突触可塑性受损是人类和小鼠模型中阿尔茨海默氏病（AD）早期记忆丧失的潜在机制。钙/钙调蛋白依赖性蛋白激酶II（CaMKII）自磷酸化的抑制作用在长期记忆中起重要作用。在这项研究中，我们从柚皮（柑橘属物种）中分离了柚皮苷，并在ADswe / PS1dE9转基因小鼠AD模型中研究了柚皮苷对长期记忆的影响。将三个月大的APPswe / PS1dE9转基因小鼠随机分为媒介物组，两个柚皮苷（50或100 mg / kg体重/天）组或Aricept（2 mg / kg体重/天）组。治疗16周后，我们观察到柚皮苷（100 mg / kg体重/天）的治疗增强了CaMKII的自磷酸化，增加了α-氨基-3-羟基-5-羟基-5-甲基-4-异恶唑丙酸（AMPA）的磷酸化）CaMKII依赖性位点的受体，并改善了长期学习和记忆能力。这些发现表明，CaMKII活性的增加可能是柚皮苷改善ADswe / PS1dE9转基因小鼠AD模型长期认知功能的机制之一。

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