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首页> 外文期刊>International journal of infectious diseases : >Interim estimates of divergence date and vaccine strain match of human influenza A(H3N2) virus from systematic influenza surveillance (2010-2015) in Hangzhou, southeast of China
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Interim estimates of divergence date and vaccine strain match of human influenza A(H3N2) virus from systematic influenza surveillance (2010-2015) in Hangzhou, southeast of China

机译：来自中国东南部杭州市的系统流感监测（2010-2015年）对人类甲型H3N2流感病毒分歧日期和疫苗株匹配的中期估计

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Objectives: In the post-pandemic period 2010-2015, seasonal influenza A(H3N2) virus predominated in Hangzhou, southeast of China, with an increased activity and semi-annual seasons. This study utilized HA virus gene segment sequences to analyze the divergence date and vaccine strain match of human influenza A(H3N2) virus from systematic influenza surveillance in Hangzhou. Methods: Virological and serological analyses of 124 representative A(H3N2) viruses from prospective studies of systematic surveillance samples were conducted to quantify the genetic and antigenic characteristics and their vaccine strain match. Results: Bayesian phylogenetic inference showed that two separate subgroups 3C.3 and 3C.2 probably diverged from group 3C in early 2012 and then evolved into groups 3C.3a and 3C.2a, respectively, in the 2014/15 influenza season. Furthermore, high amino acid substitution rates of the HA1 subunit were found in A(H3N2) group 3C.2a variants, indicating that increased antigenic drift of A(H3N2) group 3C.2a virus is associated with a vaccine mismatch to the 2015/16 vaccine reference strain Switzerland/9715293/2013 (group 3C.3a). Conclusions: A portion of the group 3C.2a isolates are not covered by the current A(H3N2) vaccine strain. These findings offer insights into the emergence of group 3C.2a variants with epidemic potential in the imminent influenza seasons.
机译：目的：在大流行后的2010-2015年期间，季节性的甲型H3N2流感病毒在中国东南部的杭州市占主导地位，活动和半年度有所增加。本研究利用HA病毒基因片段序列，通过杭州市系统性流感监测，分析了人类甲型H3N2流感病毒的分歧日期和疫苗株匹配。方法：对来自系统监测样本的前瞻性研究中的124种代表性A（H3N2）病毒进行了病毒学和血清学分析，以量化其遗传和抗原特性及其疫苗株匹配。结果：贝叶斯系统发育推断表明，两个单独的亚组3C.3和3C.2可能在2012年初脱离了3C组，然后在2014/15流感季节分别演变为3C.3a和3C.2a组。此外，在A（H3N2）3C.2a组变体中发现了HA1亚基的高氨基酸取代率，表明A（H3N2）3C.2a组病毒的抗原漂移增加与疫苗与2015/16错配有关疫苗参考菌株Switzerland / 9715293/2013（3C.3a组）。结论：当前的A（H3N2）疫苗株未涵盖3C.2a组分离株的一部分。这些发现为即将到来的流感季节中具有流行潜力的3C.2a组变种的出现提供了见识。

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