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首页> 外文期刊>International Journal of Molecular Sciences >Bax Inhibitor-1, a Conserved Cell Death Suppressor, Is a Key Molecular Switch Downstream from a Variety of Biotic and Abiotic Stress Signals in Plants
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Bax Inhibitor-1, a Conserved Cell Death Suppressor, Is a Key Molecular Switch Downstream from a Variety of Biotic and Abiotic Stress Signals in Plants

机译：Bax抑制剂1，一种保守的细胞死亡抑制剂，是植物体内多种生物和非生物胁迫信号下游的关键分子开关。

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In Nature plants are constantly challenged by a variety of environmental stresses that could lead to disruptions in cellular homeostasis. Programmed cell death (PCD) is a fundamental cellular process that is often associated with defense responses to pathogens, during development and in response to abiotic stresses in fungi, animals and plants. Although there are many characteristics shared between different types of PCD events, it remains unknown whether a common mechanism drives various types of PCD in eukaryotes. One candidate regulator for such a mechanism is Bax Inhibitor-1 (BI-1), an evolutionary conserved, endoplasmic reticulum (ER)-resident protein that represents an ancient cell death regulator that potentially regulates PCD in all eukaryotes. Recent findings strongly suggested that BI-1 plays an important role in the conserved ER stress response pathway to modulate cell death induction in response to multiple types of cell death signals. As ER stress signaling pathways has been suggested to play important roles not only in the control of ER homeostasis but also in other biological processes such as the response to pathogens and abiotic stress in plants, BI-1 might function to control the convergence point that modulates the level of the “pro-survival and pro-death” signals under multiple stress conditions.
机译：在自然界中，植物不断受到各种环境压力的挑战，这些环境压力可能导致细胞体内稳态的破坏。程序性细胞死亡（PCD）是一个基本的细胞过程，通常与真菌，动植物的发育过程中以及对非生物胁迫的反应有关，对病原体的防御反应有关。尽管在不同类型的PCD事件之间有许多共同的特征，但是，是否有共同的机制驱动真核生物中各种PCD仍然未知。这种机制的一种候选调节剂是Bax Inhibitor-1（BI-1），它是一种进化保守的内质网（ER）驻留蛋白，代表一种古老的细胞死亡调节剂，可潜在地调节所有真核生物中的PCD。最新发现强烈表明，BI-1在保守的ER应激反应途径中起重要作用，以调节细胞死亡诱导，以响应多种类型的细胞死亡信号。由于内质网应激信号传导途径不仅在内质网稳态控制中起着重要作用，而且在其他生物过程（例如对植物中病原体和非生物胁迫的反应）中也起着重要作用，因此BI-1可能起到控制调节基因的收敛点的作用。在多种压力条件下的“生存和死亡”信号的水平。

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