...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Molecular Sciences >To Remove or Not to Remove? The Challenge of Extracting the Template to Make the Cavities Available in Molecularly Imprinted Polymers (MIPs)
【24h】

To Remove or Not to Remove? The Challenge of Extracting the Template to Make the Cavities Available in Molecularly Imprinted Polymers (MIPs)

机译：要删除还是不删除？提取模板以使腔体可用于分子印迹聚合物（MIP）的挑战

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Template removal is a critical step in the preparation of most molecularly imprinted polymers (MIPs). The polymer network itself and the affinity of the imprinted cavities for the template make its removal hard. If there are remaining template molecules in the MIPs, less cavities will be available for rebinding, which decreases efficiency. Furthermore, if template bleeding occurs during analytical applications, errors will arise. Despite the relevance to the MIPs performance, template removal has received scarce attention and is currently the least cost-effective step of the MIP development. Attempts to reach complete template removal may involve the use of too drastic conditions in conventional extraction techniques, resulting in the damage or the collapse of the imprinted cavities. Advances in the extraction techniques in the last decade may provide optimized tools. The aim of this review is to analyze the available data on the efficiency of diverse extraction techniques for template removal, paying attention not only to the removal yield but also to MIPs performance. Such an analysis is expected to be useful for opening a way to rational approaches for template removal (minimizing the costs of solvents and time) instead of the current trial-and-error methods.
机译：模板去除是制备大多数分子印迹聚合物（MIP）的关键步骤。聚合物网络本身以及压印模腔对模板的亲和力使其难以去除。如果MIP中剩余模板分子，则更少的空洞可用于重新结合，从而降低了效率。此外，如果在分析应用过程中发生模板渗色，则会出现错误。尽管与MIP的性能相关，但是模板删除却很少受到关注，并且目前是MIP开发中成本最低的步骤。试图完全去除模板的尝试可能涉及在常规提取技术中使用过于剧烈的条件，从而导致压印腔体的损坏或塌陷。过去十年中提取技术的进步可能提供了优化的工具。这篇综述的目的是分析有关用于模板去除的各种提取技术的效率的可用数据，不仅要注意去除率，还要注意MIP的性能。预期这样的分析将为开辟一种合理的模板去除方法（最大限度地减少溶剂和时间的成本）而不是当前的反复试验方法提供帮助。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号