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首页> 外文期刊>International Journal of Molecular Sciences >Impact of Prematurity and Perinatal Antibiotics on the Developing Intestinal Microbiota: A Functional Inference Study
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Impact of Prematurity and Perinatal Antibiotics on the Developing Intestinal Microbiota: A Functional Inference Study

机译：早产和围产期抗生素对发育中的肠道菌群的影响：功能推断研究。

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Background: The microbial colonization of the neonatal gut provides a critical stimulus for normal maturation and development. This process of early microbiota establishment, known to be affected by several factors, constitutes an important determinant for later health. Methods: We studied the establishment of the microbiota in preterm and full-term infants and the impact of perinatal antibiotics upon this process in premature babies. To this end, 16S rRNA gene sequence-based microbiota assessment was performed at phylum level and functional inference analyses were conducted. Moreover, the levels of the main intestinal microbial metabolites, the short-chain fatty acids (SCFA) acetate, propionate and butyrate, were measured by Gas-Chromatography Flame ionization/Mass spectrometry detection. Results: Prematurity affects microbiota composition at phylum level, leading to increases of Proteobacteria and reduction of other intestinal microorganisms. Perinatal antibiotic use further affected the microbiota of the preterm infant. These changes involved a concomitant alteration in the levels of intestinal SCFA. Moreover, functional inference analyses allowed for identifying metabolic pathways potentially affected by prematurity and perinatal antibiotics use. Conclusion: A deficiency or delay in the establishment of normal microbiota function seems to be present in preterm infants. Perinatal antibiotic use, such as intrapartum prophylaxis, affected the early life microbiota establishment in preterm newborns, which may have consequences for later health.
机译：背景：新生儿肠道内的微生物定殖为正常成熟和发育提供了关键的刺激。已知会受到多种因素影响的早期微生物群建立过程，是以后健康状况的重要决定因素。方法：我们研究了早产儿和足月儿的微生物群的建立以及早产儿围产期抗生素对该过程的影响。为此，在门水平进行了基于16S rRNA基因序列的微生物群评估，并进行了功能推断分析。此外，通过气相色谱法火焰离子化/质谱检测法检测了主要肠道微生物代谢产物乙酸盐，丙酸和丁酸的短链脂肪酸（SCFA）的水平。结果：早产会影响门类的微生物群组成，从而导致变形杆菌增加和其他肠道微生物减少。围产期抗生素的使用进一步影响了早产儿的微生物群。这些改变涉及肠SCFA水平的同时改变。此外，功能推论分析可以确定可能受早产和围产期抗生素使用影响的代谢途径。结论：早产儿似乎缺乏正常菌群功能的建立或延迟。围产期抗生素的使用，例如产前预防，影响了早产儿早期生命菌群的建立，可能对以后的健康造成影响。

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