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首页> 外文期刊>International Journal of Molecular Sciences >Uric Acid and Xanthine Levels in Pregnancy Complicated by Gestational Diabetes Mellitus—The Effect on Adverse Pregnancy Outcomes
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Uric Acid and Xanthine Levels in Pregnancy Complicated by Gestational Diabetes Mellitus—The Effect on Adverse Pregnancy Outcomes

机译：妊娠期糖尿病并发尿酸和黄嘌呤水平对不良妊娠结局的影响

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摘要

Uric acid (UA) levels are associated with many diseases including those related to lifestyle. The aim of this study was to evaluate the influence of clinical and anthropometric parameters on UA and xanthine (X) levels during pregnancy and postpartum in women with physiological pregnancy and pregnancy complicated by gestational diabetes mellitus (GDM), and to evaluate their impact on adverse perinatal outcomes. A total of 143 participants were included. Analyte levels were determined by HPLC with ultraviolet detection (HPLC-UV). Several single-nucleotide polymorphisms (SNPs) in UA transporters were genotyped using commercial assays. UA levels were higher within GDM women with pre-gestational obesity, those in high-risk groups, and those who required insulin during pregnancy. X levels were higher in the GDM group during pregnancy and also postpartum. Positive correlations between UA and X levels with body mass index (BMI) and glycemia levels were found. Gestational age at delivery was negatively correlated with UA and X levels postpartum. Postpartum X levels were significantly higher in women who underwent caesarean sections. Our data support a possible link between increased UA levels and a high-risk GDM subtype. UA levels were higher among women whose glucose tolerance was severely disturbed. Mid-gestational UA and X levels were not linked to adverse perinatal outcomes.
机译：尿酸（UA）含量与许多疾病有关，包括与生活方式有关的疾病。这项研究的目的是评估临床和人体测量学参数对生理性妊娠和妊娠合并妊娠糖尿病（GDM）的妇女在怀孕和产后UA和黄嘌呤（X）水平的影响，并评估其对不良反应的影响围产期结局。共有143名参与者。通过具有紫外检测的HPLC（HPLC-UV）测定分析物水平。使用商业测定对UA转运蛋白中的几个单核苷酸多态性（SNP）进行基因分型。妊娠前肥胖的GDM女性，高危人群和妊娠期需要胰岛素的人群中UA水平较高。 GDM组在怀孕期间和产后X值均较高。发现UA和X水平与体重指数（BMI）和血糖水平呈正相关。分娩时的胎龄与产后UA和X水平呈负相关。接受剖腹产的妇女产后X水平明显更高。我们的数据支持增加的UA水平和高风险的GDM亚型之间的可能联系。在葡萄糖耐量受到严重干扰的女性中，UA水平较高。妊娠中期UA和X水平与围生期不良结果无关。

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