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首页> 外文期刊>International Journal of Molecular Sciences >Do Matrix Metalloproteases and Tissue Inhibitors of Metalloproteases in Tenocytes of the Rotator Cuff Differ with Varying Donor Characteristics?
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Do Matrix Metalloproteases and Tissue Inhibitors of Metalloproteases in Tenocytes of the Rotator Cuff Differ with Varying Donor Characteristics?

机译：肩袖肌腱细胞中的基质金属蛋白酶和金属蛋白酶组织抑制剂是否具有不同的供体特征？

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摘要

An imbalance between matrix metalloproteases (MMPs) and the tissue inhibitors of metalloproteases (TIMPs) may have a negative impact on the healing of rotator cuff tears. The aim of the project was to assess a possible relationship between clinical and radiographic characteristics of patients such as the age, sex, as well as the degenerative status of the tendon and the MMPs and TIMPs in their tenocyte-like cells (TLCs). TLCs were isolated from ruptured supraspinatus tendons and quantitative Real-Time PCR and ELISA was performed to analyze the expression and secretion of MMPs and TIMPs. In the present study, MMPs, mostly gelatinases and collagenases such as MMP-2, -9 and -13 showed an increased expression and protein secretion in TLCs of donors with higher age or degenerative status of the tendon. Furthermore, the expression and secretion of TIMP-1, -2 and -3 was enhanced with age, muscle fatty infiltration and tear size. The interaction between MMPs and TIMPs is a complex process, since TIMPs are not only inhibitors, but also activators of MMPs. This study shows that MMPs and TIMPs might play an important role in degenerative tendon pathologies.
机译：基质金属蛋白酶（MMPs）和金属蛋白酶组织抑制剂（TIMPs）之间的不平衡可能会对肩袖撕裂的愈合产生负面影响。该项目的目的是评估患者的临床和影像学特征之间的可能关系，例如年龄，性别以及肌腱及其肌腱样细胞（TLC）中的MMP和TIMP的退化状态。从断裂的棘上肌腱分离出TLC，并进行定量实时PCR和ELISA分析MMP和TIMP的表达和分泌。在本研究中，MMPs（主要是明胶酶和胶原酶，例如MMP-2，-9和-13）在具有较高年龄或腱变性状态的供体的TLC中显示出增加的表达和蛋白质分泌。此外，TIMP-1，-2和-3的表达和分泌随着年龄，肌肉脂肪浸润和泪液大小的增加而增强。 MMP和TIMP之间的相互作用是一个复杂的过程，因为TIMP不仅是MMP的抑制剂，而且是其激活剂。这项研究表明，MMP和TIMP可能在肌腱变性病理中起重要作用。

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