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首页> 外文期刊>International Journal of Molecular Sciences >Expression and Significance of CD44, CD47 and c-met in Ovarian Clear Cell Carcinoma
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Expression and Significance of CD44, CD47 and c-met in Ovarian Clear Cell Carcinoma

机译：CD44，CD47和c-met在卵巢透明细胞癌中的表达及意义

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Aims: The aim of the present study is to investigate the differential expression of CD44, CD47 and c-met in ovarian clear cell carcinoma (OCCC), the correlation in their expression and their relationship with the biological behavior of OCCC. Methods: We used immunohistochemistry to examine the expression of CD44, CD47 and c-met in OCCC (86 cases) and investigated the effects of the expression and interaction of these molecules on the development of OCCC. Results: CD44, CD47 and c-met expression was significantly high in OCCC. Expression of CD44 and CD47 correlated with patient surgical stage, chemotherapy resistance and prognosis (all p 0.05), and expression of c-met correlated with chemotherapy resistance and prognosis (all p 0.05), but did not correlate with lymph node metastasis (all p 0.05). The surgical stage, CD44, CD47 and c-met expression were independent risk factors for OCCC prognosis (all p 0.05). Patients with low levels of CD44, CD47 and c-met showed better survival than those with high levels (all p 0.05). There was a positive correlation between CD44 (or CD47) and c-met, as well as between CD44 and CD47 (the Spearman correlation coefficient rs was 0.783, 0.776 and 0.835, respectively, all p 0.01). Additionally, pairwise correlation analysis of these three markers shows that the high expression of CD44/CD47, CD44/c-met and CD47/c-met were correlated with patient surgical stage, chemotherapy resistance and prognosis (all p 0.05), but did not correlate with lymph node metastasis (all p 0.05). Conclusions: Expression of CD44, CD47 and c-met was upregulated in OCCC and pairwise correlation. CD44, CD47 and c-met may have synergistic effects on the development of OCCC and are prognostic factors for ovarian cancer.
机译：目的：本研究的目的是研究CD44，CD47和c-met在卵巢透明细胞癌（OCCC）中的差异表达，它们之间的相关性及其与OCCC生物学行为的关系。方法：我们使用免疫组化方法检测了OCCC中CD44，CD47和c-met的表达（86例），并研究了这些分子的表达和相互作用对OCCC发育的影响。结果：OCCC中的CD44，CD47和c-met表达显着较高。 CD44和CD47的表达与患者的手术分期，化疗耐药性和预后相关（均p <0.05），而c-met的表达与化疗耐药和预后相关（均p <0.05），但与淋巴结转移无关（所有p> 0.05）。手术阶段，CD44，CD47和c-met表达是OCCC预后的独立危险因素（所有p <0.05）。 CD44，CD47和c-met水平低的患者比高水平的患者表现出更好的生存率（所有p <0.05）。 CD44（或CD47）与c-met之间以及CD44与CD47之间存在正相关（Spearman相关系数r 分别为0.783、0.776和0.835，所有p <0.01 ）。此外，这三个标志物的成对相关分析表明，CD44 / CD47，CD44 / c-met和CD47 / c-met的高表达与患者的手术分期，化疗耐药性和预后相关（所有p <0.05），但确实与淋巴结转移无关（所有p> 0.05）。结论：OCCC中CD44，CD47和c-met的表达上调，且成对相关。 CD44，CD47和c-met可能对OCCC的发生具有协同作用，并且是卵巢癌的预后因素。

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