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首页> 外文期刊>International Journal of Molecular Sciences >Anti-Atherosclerotic Effects of a Phytoestrogen-Rich Herbal Preparation in Postmenopausal Women
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Anti-Atherosclerotic Effects of a Phytoestrogen-Rich Herbal Preparation in Postmenopausal Women

机译：富含植物雌激素的草药制剂对绝经后妇女的抗动脉粥样硬化作用

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The risk of cardiovascular disease and atherosclerosis progression is significantly increased after menopause, probably due to the decrease of estrogen levels. The use of hormone replacement therapy (HRT) for prevention of cardiovascular disease in older postmenopausal failed to meet expectations. Phytoestrogens may induce some improvements in climacteric symptoms, but their effect on the progression of atherosclerosis remains unclear. The reduction of cholesterol accumulation at the cellular level should lead to inhibition of the atherosclerotic process in the arterial wall. The inhibition of intracellular lipid deposition with isoflavonoids was suggested as the effective way for the prevention of plaque formation in the arterial wall. The aim of this double-blind, placebo-controlled clinical study was to investigate the effect of an isoflavonoid-rich herbal preparation on atherosclerosis progression in postmenopausal women free of overt cardiovascular disease. One hundred fifty-seven healthy postmenopausal women (age 65 ± 6) were randomized to a 500 mg isoflavonoid-rich herbal preparation containing tannins from grape seeds, green tea leaves, hop cone powder, and garlic powder, or placebo. Conventional cardiovascular risk factors and intima-media thickness of common carotid arteries (cIMT) were evaluated at the baseline and after 12 months of treatment. After 12-months follow-up, total cholesterol decreased by 6.3% in isoflavonoid-rich herbal preparation recipients ( p = 0.011) and by 5.2% in placebo recipients ( p = 0.020); low density lipoprotein (LDL) cholesterol decreased by 7.6% in isoflavonoid-rich herbal preparation recipients ( p = 0.040) and by 5.2% in placebo recipients (non-significant, NS); high density lipoprotein (HDL) cholesterol decreased by 3.4% in isoflavonoid-rich herbal preparation recipients (NS) and by 4.5% in placebo recipients ( p = 0.038); triglycerides decreased by 6.0% in isoflavonoid-rich herbal preparation recipients (NS) and by 7.1% in placebo recipients (NS). The differences between lipid changes in the isoflavonoid-rich herbal preparation and placebo recipients did not reach statistical significance ( p > 0.05). Nevertheless, the mean cIMT progression was significantly lower in isoflavonoid-rich herbal preparation recipients as compared to the placebo group (6 μm, or <1%, versus 100 μm, or 13%; p < 0.001 for the difference). The growth of existing atherosclerotic plaques in isoflavonoid-rich herbal preparation recipients was inhibited by 1.5-fold (27% versus 41% in the placebo group). The obtained results demonstrate that the use of isoflavonoid-rich herbal preparation in postmenopausal women may suppress the formation of new atherosclerotic lesions and reduce the progression of existing ones, thus promising new drug for anti-atherosclerotic therapy. Nevertheless, further studies are required to confirm these findings.
机译：绝经后心血管疾病和动脉粥样硬化进展的风险显着增加，可能是由于雌激素水平降低所致。使用激素替代疗法（HRT）预防更年期绝经后的心血管疾病未能达到预期的效果。植物雌激素可能会导致更年期症状有所改善，但其对动脉粥样硬化进展的影响尚不清楚。胆固醇在细胞水平上的减少应导致对动脉壁动脉粥样硬化过程的抑制。异黄酮抑制细胞内脂质沉积被认为是预防动脉壁斑块形成的有效方法。这项双盲，安慰剂对照临床研究的目的是研究富含异黄酮的草药制剂对无明显心血管疾病的绝经后妇女动脉粥样硬化进展的影响。 157名健康的绝经后妇女（65±6岁）被随机分配到500 mg富含异黄酮的草药制剂中，该制剂含有来自葡萄籽，绿茶叶，蛇麻草粉和大蒜粉或安慰剂的单宁。在基线和治疗12个月后评估常规的心血管危险因素和颈总动脉内膜中层厚度（cIMT）。随访12个月后，富含异黄酮的草药制剂接受者的总胆固醇降低了6.3％（p = 0.011），而安慰剂接受者的总胆固醇降低了5.2％（p = 0.020）;低密度脂蛋白（LDL）胆固醇在富含异黄酮的草药制剂接受者中降低了7.6％（p = 0.040），在安慰剂接受者中降低了5.2％（非显着性，NS）;富含异黄酮的草药制剂接受者（NS）的高密度脂蛋白（HDL）胆固醇降低3.4％，而安慰剂接受者的高密度脂蛋白（HDL）胆固醇降低4.5％（p = 0.038）;富含异黄酮的草药制剂接受者（NS）的甘油三酸酯下降6.0％，而安慰剂接受者（NS）的甘油三酯下降7.1％。富含异黄酮的草药制剂和安慰剂接受者的脂质变化之间的差异未达到统计学显着性（p> 0.05）。然而，与安慰剂组相比，富含异黄酮的草药制剂接受者的平均cIMT进展显着较低（6μm，或<1％，而100μm，或13％;差异p <0.001）。在富含异黄酮的草药制剂接受者中，现有动脉粥样硬化斑块的生长被抑制了1.5倍（安慰剂组为27％，而安慰剂组为41％）。获得的结果表明，在绝经后妇女中使用富含异黄酮的草药制剂可以抑制新的动脉粥样硬化病变的形成并减少现有病变的进展，因此有望成为抗动脉粥样硬化疗法的新药。然而，需要进一步的研究来证实这些发现。

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