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首页> 外文期刊>International Journal of Molecular Sciences >Tumor Dormancy and Interplay with Hypoxic Tumor Microenvironment
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Tumor Dormancy and Interplay with Hypoxic Tumor Microenvironment

机译：缺氧性肿瘤微环境与肿瘤休眠

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The tumor microenvironment is a key factor in disease progression, local resistance, immune-escaping, and metastasis. The rapid proliferation of tumor cells and the aberrant structure of the blood vessels within tumors result in a marked heterogeneity in the perfusion of the tumor tissue with regions of hypoxia. Although most of the tumor cells die in these hypoxic conditions, a part of them can adapt and survive for many days or months in a dormant state. Dormant tumor cells are characterized by cell cycle arrest in G0/G1 phase as well as a low metabolism, and are refractive to common chemotherapy, giving rise to metastasis. Despite these features, the cells retain their ability to proliferate when conditions improve. An understanding of the regulatory machinery of tumor dormancy is essential for identifying early cancer biomarkers and could provide a rationale for the development of novel agents to target dormant tumor cell populations. In this review, we examine the current knowledge of the mechanisms allowing tumor dormancy and discuss the crucial role of the hypoxic microenvironment in this process.
机译：肿瘤微环境是疾病进展，局部抵抗，免疫逃逸和转移的关键因素。肿瘤细胞的快速增殖和肿瘤内血管的异常结构导致在低氧区域的肿瘤组织灌注中明显异质性。尽管大多数肿瘤细胞在这些低氧条件下死亡，但它们的一部分可以适应并在休眠状态下存活数天或数月。休眠的肿瘤细胞的特征在于细胞周期停滞在G0 / G1期以及新陈代谢低，并且对普通化学疗法具有抵抗力，从而导致转移。尽管具有这些特征，但是当条件改善时，细胞仍保持其增殖能力。对肿瘤休眠调控机制的理解对于鉴定早期癌症生物标记物至关重要，并且可以为开发靶向休眠肿瘤细胞群体的新型药物提供理论依据。在这篇综述中，我们检查了目前允许肿瘤休眠的机制的知识，并讨论了低氧微环境在此过程中的关键作用。

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