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首页> 外文期刊>International Journal of Molecular Sciences >The Essential Role of Vitellogenin Receptor in Ovary Development and Vitellogenin Uptake in Bactrocera dorsalis (Hendel)
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The Essential Role of Vitellogenin Receptor in Ovary Development and Vitellogenin Uptake in Bactrocera dorsalis (Hendel)

机译：卵黄蛋白受体在卵巢小实蝇的发育和卵黄蛋白摄取中的重要作用（Hendel）

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The vitellogenin receptor (VgR) functions as an essential component in uptaking and transporting vitellogenin (Vg) in female adults, which is involved in ovary development and oviposition. This study aimed to clarify the molecular characteristics and function of VgR in the oriental fruit fly Bactrocera dorsalis (Hendel). Here, we identified the full-length of BdVgR (GenBank Accession No. JX469118), encoding a 1925 residue (aa) protein with a 214.72 kDa molecular mass and several typical motifs of low-density lipoprotein receptor superfamily (LDLR). Phylogenic analysis suggested that BdVgR was evolutionary conserved with other Dipteran VgRs. The expression of BdVgR was exclusively detected in the ovaries rather than head, thorax or other tissues. The developmental expression patterns showed that the signal of BdVgR was detectable in very beginning of adult stage, and positively correlated with the growth rate of ovaries and the expression levels of its ligands. In addition, we also demonstrated that the expression level of BdVgR, and ovary development were significantly suppressed after being injected with BdVgR-targeted dsRNA. Together, all of these results indicated that BdVgR was critical for yolk protein absorption and ovary maturation in B. dorsalis, playing a vital role in female reproduction.
机译：卵黄蛋白原受体（VgR）是成年女性摄取和运输卵黄蛋白原（Vg）的必需成分，其参与卵巢发育和产卵。本研究旨在阐明东方果蝇Bactrocera dorsalis（Hendel）中VgR的分子特征和功能。在这里，我们确定了BdVgR的全长（GenBank登录号JX469118），该蛋白编码具有194.72 kDa分子质量的1925个残基（aa）蛋白和低密度脂蛋白受体超家族（LDLR）的几个典型基序。系统发育分析表明，BdVgR与其他Dipteran VgRs在进化上是保守的。 BdVgR的表达仅在卵巢中检测到，而不是在头部，胸部或其他组织中检测到。发育表达模式表明，BdVgR信号在成年初期就可检测到，并且与卵巢的生长速度及其配体的表达水平呈正相关。此外，我们还证明了在注射靶向BdVgR的dsRNA后，BdVgR的表达水平和卵巢发育被显着抑制。总之，所有这些结果表明BdVgR对于背侧双歧杆菌卵黄蛋白的吸收和卵巢成熟至关重要，在女性生殖中起着至关重要的作用。

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