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首页> 外文期刊>International Journal of Molecular Sciences >Transactivation of Epidermal Growth Factor Receptor by G Protein-Coupled Receptors: Recent Progress, Challenges and Future Research
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Transactivation of Epidermal Growth Factor Receptor by G Protein-Coupled Receptors: Recent Progress, Challenges and Future Research

机译：G蛋白偶联受体对表皮生长因子受体的反式激活：最新进展，挑战和未来研究。

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Both G protein-coupled receptors (GPCRs) and receptor-tyrosine kinases (RTKs) regulate large signaling networks, control multiple cell functions and are implicated in many diseases including various cancers. Both of them are also the top therapeutic targets for disease treatment. The discovery of the cross-talk between GPCRs and RTKs connects these two vast signaling networks and complicates the already complicated signaling networks that regulate cell signaling and function. In this review, we focus on the transactivation of epidermal growth factor receptor (EGFR), a subfamily of RTKs, by GPCRs. Since the first report of EGFR transactivation by GPCR, significant progress has been made including the elucidation of the mechanisms underlying the transactivation. Here, we first provide a basic picture for GPCR, EGFR and EGFR transactivation by GPCR. We then discuss the progress made in the last five years and finally provided our view of the future challenge and future researches needed to overcome these challenges.
机译：G蛋白偶联受体（GPCR）和受体酪氨酸激酶（RTK）都可调节大型信号网络，控制多种细胞功能，并涉及包括多种癌症在内的许多疾病。它们都是疾病治疗的主要治疗靶标。 GPCR和RTK之间的串扰的发现将这两个庞大的信号网络连接在一起，并使调节细胞信号和功能的已经复杂的信号网络变得复杂。在这篇综述中，我们着重于通过GPCRs对RTKs的一个亚家族-表皮生长因子受体（EGFR）的反式激活。自从通过GPCR进行EGFR反式激活的第一个报道以来，已经取得了重大进展，包括阐明了反式激活的机制。在这里，我们首先提供GPCR，GPCR和EGFR反式激活的基本情况。然后，我们讨论了过去五年中取得的进展，并最终提出了我们对未来挑战的看法以及克服这些挑战所需的未来研究。

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