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首页> 外文期刊>International Journal of Molecular Sciences >The Glutathione Derivative, GSH Monoethyl Ester, May Effectively Whiten Skin but GSH Does Not
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The Glutathione Derivative, GSH Monoethyl Ester, May Effectively Whiten Skin but GSH Does Not

机译：谷胱甘肽衍生物GSH单乙基酯可以有效美白皮肤，但GSH不能

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Glutathione in its reduced form (GSH) is an antioxidant and also is involved in pheomelanin formation. Thus, it has been long believed that GSH has a skin whitening effect. However, its actual or direct effect is unproven. We evaluated the anti-melanogenic effects of GSH and its derivatives in vitro . We examined change of melanogenesis and its related proteins by GSH itself and its derivatives, including GSH monoethyl ester (GSH-MEE), GSH diethyl ester (GSH-DEE) and GSH monoisopropyl ester (GSH-MIPE) in Melan-A cells, Mel-Ab cells, and B16F10 cells. GSH and GSH-MEE did not display cytotoxic activity, but GSH-MIPE and GSH-DEE did. Intriguingly, GSH itself had no inhibitory effect on melanin production or intracellular tyrosinase activity. Rather, it was GSH-MEE and GSH-MIPE that profoundly reduced the amount of melanin and intracellular tyrosinase activity. Thus, GSH-MEE was selected as a suitable candidate skin-whitening agent and it did not alter melanogenesis-associated proteins such as microphthalmia-associated transcription factor (MITF), tyrosinase, tyrosinase-related protein (TRP)-1, and TRP-2, but it did increase the amount of suggested pheomelanin and suggested pheomelanin/eumelanin ratio. GSH-MEE was effective for anti-melanogenesis, whereas GSH itself was not. GSH-MEE could be developed as a safe and efficient agent for the treatment of hyperpigmentation skin disorders.
机译：还原型谷胱甘肽（GSH）是一种抗氧化剂，也参与了苯丙氨酸甲酯的形成。因此，长期以来一直认为GSH具有美白皮肤的作用。但是，其实际或直接效果尚未得到证实。我们评估了GSH及其衍生物在体外的抗黑色素生成作用。我们研究了Melan-A细胞，Mel中GSH本身及其衍生物（包括GSH单乙酯（GSH-MEE），GSH二乙酯（GSH-DEE）和GSH单异丙酯（GSH-MIPE））黑色素生成及其相关蛋白的变化-Ab细胞和B16F10细胞。 GSH和GSH-MEE没有显示细胞毒活性，但是GSH-MIPE和GSH-DEE却显示出细胞毒活性。有趣的是，GSH本身对黑色素生成或细胞内酪氨酸酶活性没有抑制作用。相反，正是GSH-MEE和GSH-MIPE大大降低了黑色素的含量和细胞内酪氨酸酶的活性。因此，选择了GSH-MEE作为合适的候选美白剂，并且它不会改变与黑色素生成相关的蛋白质，如小眼症相关的转录因子（MITF），酪氨酸酶，酪氨酸酶相关的蛋白质（TRP）-1和TRP- 2，但确实增加了建议的苯丙氨酸的量和建议的苯丙氨酸/双甘氨酸比。 GSH-MEE对抗黑色素生成有效，而GSH本身无效。可以将GSH-MEE开发为治疗色素沉着过度皮肤病的安全有效的药物。

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