...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Molecular Sciences >Punicalagin Mollifies Lead Acetate-Induced Oxidative Imbalance in Male Reproductive System
【24h】

Punicalagin Mollifies Lead Acetate-Induced Oxidative Imbalance in Male Reproductive System

机译：葛根素缓解男性生殖系统中乙酸铅诱导的氧化不平衡。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Punicalagin (PU) is a known antioxidant. The present study examined PU to protect against lead-induced oxidative stress (OS) testicular damage in mice. Significant increase in lipid peroxidation (LPO) after intraperitoneal injection of lead acetate (LA) indicated enormous generation of reactive oxygen species (ROS). Lead-induced OS has a direct effect on the differentiation of spermatogonial cells, showing a significant decline in sperm count. Supplementation of PU significantly changes values of LPO and glutathione (GSH) with a concomitant increase in sperm count, a marked decrease in the abnormal sperms, and a decline in the morphologically abnormal sperm population. Moreover, the histopathological evaluation of testes and epididymides showed severe changes in mice treated with LA. PU significantly induced nuclear factor erythroid-2 related factor 2-like 2 (Nrf2) expression and phase II enzymes, and data suggest that PU may inhibit OS through Nrf2 activation. The fertility test proved that PU might play an important role in male infertility treatment, especially in the type of infertility induced by OS.
机译：石榴皮（PU）是一种已知的抗氧化剂。本研究检查了PU，以防止小鼠铅诱导的氧化应激（OS）睾丸损伤。腹腔内注射乙酸铅（LA）后脂质过氧化（LPO）的显着增加表明活性氧（ROS）的大量产生。铅诱导的OS对精原细胞的分化有直接影响，显示精子数量显着下降。补充PU会显着改变LPO和谷胱甘肽（GSH）的值，并伴有精子数量的增加，异常精子的显着减少以及形态异常的精子数量的减少。此外，睾丸和附睾的组织病理学评估显示，用LA治疗的小鼠发生了严重变化。 PU显着诱导核因子erythroid-2相关因子2样2（Nrf2）表达和II期酶，并且数据表明PU可能通过Nrf2激活抑制OS。生育力测试证明，PU可能在男性不育治疗中起着重要作用，尤其是在OS引起的不育类型中。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号