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首页> 外文期刊>Investigative ophthalmology & visual science >Hispanic Ethnicity Impacts Presentation, Treatment, and Survival of Uveal Melanoma: A Seer Study
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Hispanic Ethnicity Impacts Presentation, Treatment, and Survival of Uveal Melanoma: A Seer Study

机译：西班牙裔种族影响葡萄膜黑色素瘤的表现，治疗和生存：先知研究

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Purpose: : Uveal melanoma is a rare disease that arises predominantly in the choroid and ciliary body. Studies have investigated the impact of Hispanic ethnicity on the incidence of uveal melanoma. However, the impact of Hispanic ethnicity on the presentation, treatment, and outcomes of uveal melanoma remain unknown. Therefore we conducted this investigation of the Surveillance, Epidemiology, and End Results (SEER) Database. Methods: : We queried the 17 SEER registries for Hispanic white (HW) and Non-Hispanic White (NHW) patients diagnosed with primary uveal melanoma from 1990 through 2006. Univariate and multivariate analyses examined predictors of receiving enucleation and radiation therapy. Cox regression analyses assessed overall relative survival (ORS) and cancer-specific survival (CSS) across patient- and disease-related characteristics. Results: : NHWs and HWs constituted 94.7% and 5.3% of the 2,070 patients who met inclusion criteria, respectively. HWs presented nearly a decade earlier in life (mean +/- SD age: 53.6 +/- 16.9) versus NHWs (mean +/- age: 60.1 +/- 15.3) (p0.001) and with more advanced disease (p=0.036). HWs were more likely to receive enucleation (OR: 1.737, 95% CI: 1.184-2.547) and less likely to receive radiation therapy (OR: 0.638, 95% CI: 0.436-0.933). Controlling for presentation and treatment differences, HWs experienced no difference in ORS or CSS. Conclusions: : HWs and NHWs significantly differ in presentation and treatment of uveal melanoma. These disparities likely lead to increased morbidity. However, HWs do not experience decreased survival. Future efforts are needed to understand and overcome potential genetic, environmental, biological, and socioeconomic contributors to these differences in presentation and treatment of uveal melanomas among Hispanic and Non-Hispanic White patients.
机译：目的：葡萄膜黑色素瘤是一种罕见的疾病，主要发生在脉络膜和睫状体中。研究调查了西班牙裔种族对葡萄膜黑色素瘤发生率的影响。然而，西班牙裔种族对葡萄膜黑色素瘤的表现，治疗和结局的影响仍然未知。因此，我们对监视，流行病学和最终结果（SEER）数据库进行了这项调查。方法：：我们对1990年至2006年诊断为原发性葡萄膜黑色素瘤的西班牙裔白人（HW）和非西班牙裔白人（NHW）患者的17个SEER登记表进行了查询。单因素和多因素分析检查了接受去核和放射治疗的预测因素。 Cox回归分析评估了患者和疾病相关特征的总体相对生存期（ORS）和癌症特异性生存期（CSS）。结果：在符合入组标准的2,070名患者中，NHW和HW分别占94.7％和5.3％。硬汉出现的时间比NHWs（平均+/-年龄：60.1 +/- 15.3）快近十年（平均+/- SD年龄：53.6 +/- 16.9）（p <0.001）并且疾病更严重（p = 0.036）。硬件专家接受摘除术的可能性更高（OR：1.737，95％CI：1.184-2.547），接受放射疗法的可能性较小（OR：0.638，95％CI：0.436-0.933）。控制表现和治疗差异后，硬件在ORS或CSS中没有差异。结论：葡萄膜黑色素瘤的表现和治疗均与硬膜外和NHW有显着差异。这些差异可能导致发病率增加。但是，硬件专家并未经历生存期的下降。在西班牙裔和非西班牙裔白人患者葡萄膜黑色素瘤的表现和治疗中，这些差异的潜在遗传，环境，生物学和社会经济影响因素尚需进一步努力。

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