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首页> 外文期刊>International Journal of Molecular Sciences >Endometriosis-Associated Ovarian Cancer: A Review of Pathogenesis
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Endometriosis-Associated Ovarian Cancer: A Review of Pathogenesis

机译：子宫内膜异位症相关的卵巢癌：发病机理的审查。

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Endometriosis is classically defined as the presence of endometrial glands and stroma outside of the endometrial lining and uterine musculature. With an estimated frequency of 5%–10% among women of reproductive age, endometriosis is a common gynecologic disorder. While in itself a benign lesion, endometriosis shares several characteristics with invasive cancer, has been shown to undergo malignant transformation, and has been associated with an increased risk of epithelial ovarian carcinoma (EOC). Numerous epidemiologic studies have shown an increased risk of EOC among women with endometriosis. This is particularly true for women with endometrioid and clear cell ovarian carcinoma. However, the carcinogenic pathways by which endometriosis associated ovarian carcinoma (EAOC) develops remain poorly understood. Current molecular studies have sought to link endometriosis with EAOC through pathways related to oxidative stress, inflammation and hyperestrogenism. In addition, numerous studies have sought to identify an intermediary lesion between endometriosis and EAOC that may allow for the identification of endometriosis at greatest risk for malignant transformation or for the prevention of malignant transformation of this common gynecologic disorder. The objective of the current article is to review the current data regarding the molecular events associated with EAOC development from endometriosis, with a primary focus on malignancies of the endometrioid and clear cell histologic sub-types.
机译：子宫内膜异位症通常定义为子宫内膜和子宫肌肉组织以外的子宫内膜腺体和间质的存在。子宫内膜异位症是常见的妇科疾病，据估计在育龄妇女中发病率为5％-10％。子宫内膜异位症虽然本身是一种良性病变，但它与浸润性癌具有多个特征，已显示出发生恶性转化，并与上皮性卵巢癌（EOC）的风险增加有关。大量的流行病学研究表明，子宫内膜异位症女性的EOC风险增加。这对于患有子宫内膜样和透明细胞卵巢癌的妇女尤其如此。然而，子宫内膜异位症相关卵巢癌（EAOC）发展的致癌途径仍知之甚少。当前的分子研究试图通过与氧化应激，炎症和雌激素过多有关的途径将子宫内膜异位症与EAOC联系起来。另外，许多研究已经试图鉴定子宫内膜异位和EAOC之间的中间病变，该中间病变可能允许鉴定处于这种常见的妇科疾病的最大风险为恶性转化或预防恶性转化的子宫内膜异位。本文的目的是回顾与子宫内膜异位症与EAOC发展相关的分子事件的当前数据，主要关注子宫内膜样癌的恶性肿瘤和透明细胞组织学亚型。

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