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首页> 外文期刊>International Journal of Molecular Sciences >PNPLA3 Expression Is Related to Liver Steatosis in Morbidly Obese Women with Non-Alcoholic Fatty Liver Disease
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PNPLA3 Expression Is Related to Liver Steatosis in Morbidly Obese Women with Non-Alcoholic Fatty Liver Disease

机译：PNPLA3表达与非酒精性脂肪肝病的病态肥胖妇女的肝脏脂肪变性有关

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Recent reports suggest a role for the Patatin-like phospholipase domain-containing protein 3 (PNPLA3) in the pathology of non-alcoholic fatty liver disease (NAFLD). Lipid deposition in the liver seems to be a critical process in the pathogenesis of NAFLD. The aim of the present work was to evaluate the association between the liver PNPLA3 expression, key genes of lipid metabolism, and the presence of NAFLD in morbidly obese women. We used real-time polymerase chain reaction (PCR) analysis to analyze the hepatic expression of PNPLA3 and lipid metabolism-related genes in 55 morbidly obese subjects with normal liver histology (NL, n = 18), simple steatosis (SS, n = 20), and non-alcoholic steatohepatitis (NASH, n = 17). Liver biopsies were collected during bariatric surgery. We observed that liver PNPLA3 expression was increased in NAFLD than in NL. It was also upregulated in SS than in NL. Interestingly, we found that the expression of PNPLA3 was significantly higher in severe than mild SS group. In addition, the expression of the transcription factors LXRα , PPARα , and SREBP2 was positively correlated with PNPLA3 liver expression. Regarding rs738409 polymorphism, GG genotype was positive correlated with the presence of NASH. In conclusion, our results show that PNPLA3 could be related to lipid accumulation in liver, mainly in the development and progression of simple steatosis.
机译：最近的报道表明，在非酒精性脂肪肝疾病（NAFLD）的病理学中，类Patatin样磷脂酶域蛋白3（PNPLA3）的作用。肝脏中的脂质沉积似乎是NAFLD发病机理中的关键过程。本工作的目的是评估病态肥胖妇女肝脏PNPLA3表达，脂质代谢关键基因和NAFLD的存在之间的关联。我们使用实时聚合酶链反应（PCR）分析来分析55名患有正常肝脏组织学（NL，n = 18），单纯脂肪变性（SS，n = 20）的病态肥胖受试者的PNPLA3和脂质代谢相关基因的肝表达）和非酒精性脂肪性肝炎（NASH，n = 17）。减肥手术期间收集肝活检。我们观察到，NAFLD的肝脏PNPLA3表达高于NL。 SS中它也比NL中上调。有趣的是，我们发现重度PNPLA3的表达明显高于轻度SS组。另外，转录因子LXRα，PPARα和SREBP2的表达与PNPLA3肝表达正相关。关于rs738409多态性，GG基因型与NASH的存在呈正相关。总之，我们的结果表明PNPLA3可能与肝脏脂质的积累有关，主要与单纯脂肪变性的发生和发展有关。

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