Hispolon Decreases Melanin Production and Induces Apoptosis in Melanoma Cells through the Downregulation of Tyrosinase and Microphthalmia-Associated Transcription Factor (MITF) Expressions and the Activation of Caspase-3, -8 and -9

Chia-Yi Liu; Chih-Chien Lin; Shu-Mei Lee; Yi-Shyan Chen

首页> 外文期刊>International Journal of Molecular Sciences >Hispolon Decreases Melanin Production and Induces Apoptosis in Melanoma Cells through the Downregulation of Tyrosinase and Microphthalmia-Associated Transcription Factor (MITF) Expressions and the Activation of Caspase-3, -8 and -9

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Hispolon Decreases Melanin Production and Induces Apoptosis in Melanoma Cells through the Downregulation of Tyrosinase and Microphthalmia-Associated Transcription Factor (MITF) Expressions and the Activation of Caspase-3, -8 and -9

机译：Hispolon通过下调酪氨酸酶和小眼症相关转录因子（MITF）的表达以及Caspase-3，-8和-9的激活来降低黑色素的生成并诱导黑色素瘤细胞凋亡。

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Hispolon is one of the most important functional compounds that forms Phellinus linteus (Berkeley & Curtis) Teng. Hispolon has antioxidant, anti-inflammatory, antiproliferative and anticancer effects. In this study, we analyzed the functions of hispolon on melanogenesis and apoptosis in B16-F10 melanoma cells. The results demonstrated that hispolon is not an enzymatic inhibitor for tyrosinase; rather, it represses the expression of tyrosinase and the microphthalmia-associated transcription factor (MITF) to reduce the production of melanin in α-melanocyte-stimulating hormone (α-MSH)-stimulated B16-F10 cells at lower concentrations (less than 2 μM). In contrast, at higher concentration (greater than 10 μM), hispolon can induce activity of caspase-3, -8 and -9 to trigger apoptosis of B16-F10 cells but not of Detroit 551 normal fibroblast cells. Therefore, we suggest that hispolon has the potential to treat hyperpigmentation diseases and melanoma skin cancer in the future.

机译：Hispolon是形成桑黄（Berkeley＆Curtis）藤的最重要的功能性化合物之一。 Hispolon具有抗氧化，抗炎，抗增殖和抗癌作用。在这项研究中，我们分析了组蛋白对B16-F10黑色素瘤细胞黑色素生成和凋亡的作用。结果表明，组蛋白不是酪氨酸酶的酶抑制剂。相反，它可抑制酪氨酸酶和小眼症相关转录因子（MITF）的表达，从而以较低的浓度（小于2μM）减少α-黑素细胞刺激激素（α-MSH）刺激的B16-F10细胞中黑色素的生成。）。相反，在更高的浓度（大于10μM）下，组蛋白可以诱导caspase-3，-8和-9的活性来触发B16-F10细胞的凋亡，而不会触发底特律551正常成纤维细胞的凋亡。因此，我们建议组蛋白在将来有可能治疗色素沉着过多的疾病和黑色素瘤皮肤癌。

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《International Journal of Molecular Sciences》 |2014年第1期|共15页
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Chia-Yi Liu; Chih-Chien Lin; Shu-Mei Lee; Yi-Shyan Chen;
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1. Hispolon Decreases Melanin Production and Induces Apoptosis in Melanoma Cells through the Downregulation of Tyrosinase and Microphthalmia-Associated Transcription Factor (MITF) Expressions and the Activation of Caspase-3, -8 and -9 [J] . Chia-Yi Liu, Chih-Chien Lin, Shu-Mei Lee, International Journal of Molecular Sciences . 2014,第1期

机译：Hispolon通过下调酪氨酸酶和小眼症相关转录因子（MITF）的表达以及Caspase-3，-8和-9的激活来降低黑色素的生成并诱导黑色素瘤细胞凋亡。
2. Baicalin-induced Akt activation decreases melanogenesis through downregulation of microphthalmia-associated transcription factor and tyrosinase [J] . Jeong Hyo-Soon, Gu Go Eun, Jo Ah Reum, European Journal of Pharmacology: An International Journal . 2015,第Null期

机译：黄ical苷诱导的Akt激活通过下调小眼科相关转录因子和酪氨酸酶来减少黑色素生成。
3. 13-cis-Retinoic Acid Induces Apoptosis by Modulating Caspase-3, bcl-2, and p53 Gene Expression and Regulates the Activation of Transcription Factors in B16F-10 Melanoma Cells. [J] . Guruvayoorappan C, Pradeep CR, Kuttan G Journal of environmental pathology, toxicology and oncology: official organ of the International Society for Environmental Toxicology and Cancer . 2008,第3期

机译：13顺式视黄酸通过调节Caspase-3，bcl-2和p53基因表达诱导凋亡，并调节B16F-10黑色素瘤细胞中转录因子的活化。
4. Inhibitors of diverse metabolic steps cause increased apoptosis in deoxyadenosine-resistantmouse leukemia L1210 cells that lack p53 expression: convergence at caspase-3 activation [C] . Ann H. Cory, Caroline C. Edwards, Jennifer G. Hall, International Symposium on Regulation of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues . 2003

机译：不同代谢步骤的抑制剂导致缺乏p53表达的脱氧腺苷抵抗疗效中的细胞凋亡增加：Caspase-3活化的收敛性
5. Methionine Stress Induces Downregulation of Cdc6 and Pre-Replication Complexes and Activates Intrinsic Apoptosis in Breast Cancer Cells. [D] . Booher, Keith Richard. 2011

机译：蛋氨酸应激诱导Cdc6和复制前复合体的下调并激活乳腺癌细胞的固有凋亡。
6. Hispolon Decreases Melanin Production and Induces Apoptosis in Melanoma Cells through the Downregulation of Tyrosinase and Microphthalmia-Associated Transcription Factor (MITF) Expressions and the Activation of Caspase-3 -8 and -9 [O] . Yi-Shyan Chen, Shu-Mei Lee, Chih-Chien Lin, 2014

机译：Hispolon通过下调酪氨酸酶和小眼症相关转录因子（MITF）的表达以及Caspase-3-8和-9的激活来减少黑色素的产生并诱导黑色素瘤细胞凋亡。
7. Hispolon Decreases Melanin Production and Induces Apoptosis in Melanoma Cells through the Downregulation of Tyrosinase and Microphthalmia-Associated Transcription Factor (MITF) Expressions and the Activation of Caspase-3, -8 and -9 [O] . Yi-Shyan Chen, Shu-Mei Lee, Chih-Chien Lin, 2014

机译：Hispolon通过下调酪氨酸酶和微小相关转录因子（mITF）表达以及Caspase-3，-8和-9的激活，减少黑色素细胞生成并诱导黑素瘤细胞凋亡

Hispolon Decreases Melanin Production and Induces Apoptosis in Melanoma Cells through the Downregulation of Tyrosinase and Microphthalmia-Associated Transcription Factor (MITF) Expressions and the Activation of Caspase-3, -8 and -9

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