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首页> 外文期刊>Investigative ophthalmology & visual science >The Effect of Pirenzepine on Positive- and Negative-Lensa??Induced Refractive Error and Ocular Growth in Chicks
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The Effect of Pirenzepine on Positive- and Negative-Lensa??Induced Refractive Error and Ocular Growth in Chicks

机译：哌仑西平对小鸡正负镜片诱导的屈光不正和眼球生长的影响

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Purpose.: The selective muscarinic antagonist pirenzepine inhibits experimentally induced myopia in avian and mammalian species, including nonhuman primates and adolescent humans. Transient positive lens defocus has a potent inhibitory effect on negative-lensa??induced myopia in avian and mammalian models. The purpose of the present study was to determine the influence of daily treatment with pirenzepine on ocular growth and refractive error in chicks wearing positive lenses. Methods.: The chicks were allocated to one of eight groups (n = 6 each group) on the basis of whether they wore +10 or a??10 D lenses monocularly and whether they received daily intravitreal injections of pirenzepine (700 ??g) or vehicle (phosphate-buffered saline) in the lens-defocused eye. In vivo refractive and biometric data were collected, and glycosaminoglycan synthesis in the sclera was assessed. Results.: Pirenzepine did not alter the level of positive-lensa??induced hyperopia in chicks wearing +10 D lenses compared with that in the vehicle control group (+8.1 ?± 0.6 D vs. +8.9 ?± 2.4 D, mean ?± SEM; P = 0.76). In contrast, pirenzepine caused significant inhibition of negative-lensa??induced myopia compared with that in the vehicle group (a??1.1 ?± 1.5 D vs. a??8.8 ?± 1.1 D; P = 0.001). Glycosaminoglycan synthesis in the posterior sclera was significantly increased in the negative-lensa??treated groups and showed small decreases in the positive-lensa??treated groups. Conclusions.: The influence of pirenzepine on ocular growth in chicks differed by sign of lens defocus, with pirenzepine blocking negative-lens effects on ocular growth, but not positive-lens effects. The most likely reason that hyperopia was not enhanced by pirenzepine treatment was that the rapid compensatory eye growth associated with positive lenses eliminated the imposed myopic defocus, and the clear retinal image prevented any additional hyperopia from developing.
机译：目的：选择性毒蕈碱拮抗剂哌仑西平可抑制鸟类和哺乳动物物种（包括非人类灵长类和青春期人类）的实验性近视。暂时性正透镜散焦对鸟类和哺乳动物模型中的负透镜引起的近视具有有效的抑制作用。本研究的目的是确定每天服用哌仑西平对戴正眼镜的雏鸡眼部生长和屈光不正的影响。方法：根据小鸡是否单眼佩戴+10或a ?? 10 D晶状体，以及是否每天接受玻璃体内注射哌仑西平（700 ?? g），将其分为八组（每组n = 6）之一。镜头散焦的眼睛）或媒介物（磷酸盐缓冲液）。收集体内屈光和生物测定数据，并评估巩膜中糖胺聚糖的合成。结果：与媒介物对照组相比，哌仑西平没有改变戴+10 D镜片的雏鸡的正镜头引起的远视的水平（+8.1？±0.6 D对+8.9？±2.4 D，均值？ ±SEM; P = 0.76）。相反，与媒介物组相比，哌仑西平对负透镜引起的近视具有显着的抑制作用（a ?? 1.1？±1.5 D与a？8.8 8.8±1.1 D; P = 0.001）。负透镜处理的组后巩膜中的糖胺聚糖合成显着增加，而正透镜处理的组中则显示出少量下降。结论：哌仑西平对小鸡的眼部生长的影响因晶状体散焦的迹象而有所不同，吡仑西平阻断了负性晶状体对眼部生长的影响，但没有正性晶状体的影响。哌仑西平治疗不能增强远视的最可能原因是与正晶状体相关的快速代偿性眼睛生长消除了强加的近视散焦，清晰的视网膜图像阻止了任何其他远视的发展。

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