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首页> 外文期刊>International Journal of Molecular Sciences >Renal Transcriptome Analysis of Programmed Hypertension Induced by Maternal Nutritional Insults
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Renal Transcriptome Analysis of Programmed Hypertension Induced by Maternal Nutritional Insults

机译：母体营养损害诱发的程序性高血压的肾脏转录组分析

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Maternal nutrition can affect development, leading to long-term effects on the health of offspring. The most common outcome is programmed hypertension. We examined whether alterations in renal transcriptome are responsible for generating programmed hypertension among four different models using next-generation RNA sequencing (NGS) technology. Pregnant Sprague-Dawley rats received 50% caloric restriction (CR), intraperitoneal injection of 45 mg/kg streptozotocin, 60% high-fructose (HF) diet, or 1% NaCl in drinking water to conduct CR, diabetes, HF, or high-salt models, respectively. All four models induced programmed hypertension in adult male offspring. We observed 16 shared genes in a two-week-old kidney among four different models. The identified differential expressed genes (DEGs) that are related to the regulation of blood pressure included Adrb3, Alb, Apoe, Calca, Kng1, Adm2, Guca2b, Hba2, Hba-a2, and Ppara. The peroxisome proliferator-activated receptor (PPAR) signaling pathway and glutathione metabolism pathway were shared by the CR, diabetes, and HF models. Conclusively, a variety of maternal nutritional insults induced the same phenotype—programmed hypertension with differential alterations of renal transcriptome in adult male offspring. The roles of DEGs identified by the NGS in this study deserve further clarification to develop ideal maternal dietary interventions and thus spare the next generations from the burden of hypertension.
机译：产妇营养会影响发育，导致对子代健康的长期影响。最常见的结果是程序性高血压。我们使用下一代RNA测序（NGS）技术检查了肾脏转录组的改变是否导致了四种不同模型之间的程序性高血压。怀孕的Sprague-Dawley大鼠接受了50％的热量限制（CR），腹腔注射45 mg / kg链脲佐菌素，60％的高果糖（HF）饮食或1％的NaCl饮用水以进行CR，糖尿病，HF或高脂饮食-盐模型。所有四个模型均在成年雄性后代中诱发了程序性高血压。我们在两个不同模型的两个星期大的肾脏中观察到16个共有基因。所确定的与血压调节相关的差异表达基因（DEG）包括Adrb3，Alb，Apoe，Calca，Kng1，Adm2，Guca2b，Hba2，Hba-a2和Ppara。 CR，糖尿病和HF模型共有过氧化物酶体增殖物激活受体（PPAR）信号传导途径和谷胱甘肽代谢途径。结论是，成年男性后代中，多种母体营养损伤均诱发了相同的表型，即程序性高血压和肾转录组的差异性改变。 NGS在本研究中确定的DEG的作用值得进一步阐明，以发展理想的孕产妇饮食干预措施，从而使下一代摆脱高血压的负担。

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