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首页> 外文期刊>International Journal of Molecular Sciences >Serum Interleukin-18, Fetuin-A, Soluble Intercellular Adhesion Molecule-1, and Endothelin-1 in Ankylosing Spondylitis, Psoriatic Arthritis, and SAPHO Syndrome
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Serum Interleukin-18, Fetuin-A, Soluble Intercellular Adhesion Molecule-1, and Endothelin-1 in Ankylosing Spondylitis, Psoriatic Arthritis, and SAPHO Syndrome

机译：强直性脊柱炎，银屑病关节炎和SAPHO综合征患者的血清白细胞介素18，胎球蛋白A，可溶性细胞间粘附分子1和内皮素1

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To examine serum interleukin 18 (IL-18), fetuin-A, soluble intercellular adhesion molecule-1 (sICAM-1), and endothelin-1 (ET-1) levels in ankylosing spondylitis (AS), psoriatic arthritis (PsA), and Synovitis Acne Pustulosis Hyperostosis Osteitis syndrome (SAPHO). We studied 81 AS, 76 PsA, and 34 SAPHO patients. We measured serum IL-18, fetuin-A, sICAM-1, ET-1, IL-6, IL-23, vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF). IL-18 levels were higher in AS ( p = 0.001), PsA ( p = 0.0003), and SAPHO ( p = 0.01) than in controls, and were positively correlated with CRP ( p = 0.03), VEGF ( p = 0.03), and total cholesterol (TC, p = 0.006) in AS and with IL-6 ( p = 0.03) in PsA. Serum fetuin-A levels were lower in AS ( p = 0.001) and PsA ( p = 0.001) than in controls, and negatively correlated with C-reactive protein (CRP) in AS ( p = 0.04) and SAPHO ( p = 0.03). sICAM-1 positively correlated with CRP ( p = 0.01), erythrocyte sedimentation rate (ESR, p = 0.01), and IL-6 ( p = 0.008) in AS, and with IL-6 ( p = 0.001) in SAPHO. Serum ET-1 levels were lower in AS ( p = 0.0005) than in controls. ET-1 positively correlated with ESR ( p = 0.04) and Disease Activity Score 28 (DAS28, p = 0.003) in PsA. In spondyloarthritis, markers of endothelial function correlated with disease activity and TC.
机译：要检查强直性脊柱炎（AS），银屑病关节炎（PsA）中的血清白介素18（IL-18），胎球蛋白A，可溶性细胞间粘附分子1（sICAM-1）和内皮素1（ET-1）的水平，和滑膜炎痤疮脓疱病骨质增生性骨炎综合征（SAPHO）。我们研究了81名AS，76名PsA和34名SAPHO患者。我们测量了血清IL-18，胎球蛋白A，sICAM-1，ET-1，IL-6，IL-23，血管内皮生长因子（VEGF）和表皮生长因子（EGF）。 AS（p = 0.001），PsA（p = 0.0003）和SAPHO（p = 0.01）的IL-18水平高于对照组，并且与CRP（p = 0.03），VEGF（p = 0.03）正相关。 ，以及AS中的总胆固醇（TC，p = 0.006）和PsA中的IL-6（p = 0.03）。 AS（p = 0.001）和PsA（p = 0.001）的血清胎球蛋白A水平低于对照组，并且与AS（p = 0.04）和SAPHO（p = 0.03）的C反应蛋白（CRP）呈负相关。 。 sICAM-1与AS中的CRP（p = 0.01），红细胞沉降率（ESR，p = 0.01）和IL-6（p = 0.008）正相关，与SAPHO中的IL-6（p = 0.001）正相关。 AS的血清ET-1水平低于对照组（p = 0.0005）。 ET-1与PsA中的ESR（p = 0.04）和疾病活动评分28（DAS28，p = 0.003）正相关。在脊椎关节炎中，内皮功能的标志物与疾病活动性和TC相关。

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