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首页> 外文期刊>International Journal of Molecular Sciences >Assembly Mechanism for Aggregation of Amyloid Fibrils
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Assembly Mechanism for Aggregation of Amyloid Fibrils

机译：淀粉样蛋白原纤维聚集的组装机制

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The assembly mechanism for aggregation of amyloid fibril is important and fundamental for any quantitative and physical descriptions because it needs to have a deep understanding of both molecular and statistical physics. A theoretical model with three states including coil, helix and sheet is presented to describe the amyloid formation. The corresponding general mathematical expression of N molecule systems are derived, including the partition function and thermodynamic quantities. We study the equilibrium properties of the system in the solution and find that three molecules have the extreme value of free energy. The denaturant effect on molecular assemble is also discussed. Furthermore, we apply the kinetic theories to take account of the nucleation and growth of the amyloid in the solution. It has been shown that our theoretical results can be compared with experimental results.
机译：淀粉样蛋白原纤维聚集的组装机制对于任何定量和物理描述都是重要和基础的，因为它需要对分子和统计物理学都有深刻的理解。提出了具有三种状态的理论模型，包括线圈，螺旋和片层，以描述淀粉样蛋白的形成。推导了N分子系统的相应一般数学表达式，包括分配函数和热力学量。我们研究了溶液中系统的平衡性质，发现三个分子具有自由能的极值。还讨论了变性对分子组装的影响。此外，我们应用动力学理论来考虑溶液中淀粉样蛋白的形核和生长。结果表明，我们的理论结果可以与实验结果进行比较。

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