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首页> 外文期刊>Investigative ophthalmology & visual science >Protective Role of Orthokeratology in Reducing Risk of Rapid Axial Elongation: A Reanalysis of Data From the ROMIO and TO-SEE StudiesProtective Role of Orthokeratology
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Protective Role of Orthokeratology in Reducing Risk of Rapid Axial Elongation: A Reanalysis of Data From the ROMIO and TO-SEE StudiesProtective Role of Orthokeratology

机译：角膜塑形术在降低快速轴伸长风险中的保护作用：对ROMIO和TO-SEE研究数据的重新分析角膜塑形术的保护作用

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Purpose:Todeterminetherelativeriskofrapidprogressionandnumberneededtotreat(NNT)inyoungerandolderchildrenusingcombineddatafromtheretardationofmyopiainorthokeratology(ROMIO)andtoricorthokeratologya€“slowingeyeelongation(TO-SEE)studies.Methods:Datafrom136subjectsoftwostudies,ROMIOandTO-SEE,wereretrieved(72orthokeratology[ortho-k]:37ROMIO,35TO-SEE;64control:41ROMIO,23TO-SEE)andthemyopiacontroleffectonyounger(6a€“8years)andolder(9a€“12years)subjectsevaluated.Therateofaxialelongationwasclassifiedasnotrapid(axialelongation=0.36mm/year)orrapid(axialelongation0.36mm/year).Results:Cumulativefrequencycurvesshowedthattheyoungersubjectsinthecontrolgrouphadthegreatestandmostrapidaxialelongationattheendof24months.Intheyoungersubjects,ortho-klenswearsignificantlyreducedtheriskofrapidprogressionby88.8%(P=0.002).The2-yearNNTfortheyoungerortho-ksubgroupwas1.8,suggestingthattreatingjusttwoyoungersubjectswithortho-kwouldpreventonesubjectfromexperiencingrapidprogressionovera2-yearperiodoftreatment.The2-yearNNTfortheolderortho-ksubgroupwas11.8,whichwasstatisticallyinsignificant(P=0.197).Conclusions:Orthokeratologysignificantlyreducedriskofrapidprogressioninyoungersubjects.Treatingjusttwo6-to8-year-oldsubjectswithortho-kinsteadofsingle-visionspectaclescouldpreventonesubjectfromdevelopingrapidlyprogressingaxialelongationduringthiscritical2-yearperiod.
机译：目的：Todeterminetherelativeriskofrapidprogressionandnumberneededtotreat（NNT）inyoungerandolderchildrenusingcombineddatafromtheretardationofmyopiainorthokeratology（ROMIO）andtoricorthokeratologya€“slowingeyeelongation（TO-SEE）studies.Methods：Datafrom136subjectsoftwostudies，ROMIOandTO-SEE，wereretrieved（72orthokeratology [邻 - k]的：37ROMIO，35TO-SEE; 64control：41ROMIO，23TO- SEE）andthemyopiacontroleffectonyounger（6A€“8年）andolder（9A€“12年）subjectsevaluated.Therateofaxialelongationwasclassifiedasnotrapid（axialelongation = LT;0.36毫米/年）orrapid（axialelongation0.36毫米/年）。结果：Cumulativefrequencycurvesshowedthattheyoungersubjectsinthecontrolgrouphadthegreatestandmostrapidaxialelongationattheendof24months.Intheyoungersubjects，邻klenswearsignificantlyreducedtheriskofrapidprogressionby88.8 ％（P = 0.002）。年轻的Ortho-k子组的2年NNT为1.8，这表明治疗2年以上使用正常的Preventone受试者的两个年轻受试者的治疗时间超过2年。较老的原k亚组的2年NNT为11.8，在统计学上无统计学意义（P = 0.197）。

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