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首页> 外文期刊>Investigative ophthalmology & visual science >In Vivo Imaging of Corneal Endothelial Dystrophy in Boston Terriers: A Spontaneous, Canine Model for Fuchs' Endothelial Corneal Dystrophy
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In Vivo Imaging of Corneal Endothelial Dystrophy in Boston Terriers: A Spontaneous, Canine Model for Fuchs' Endothelial Corneal Dystrophy

机译：波士顿梗犬角膜内皮营养不良的体内成像：Fuchs内皮角膜营养不良的自发犬模型。

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Purpose: Boston Terriers (BTs) have a greater prevalence of corneal endothelial dystrophy (CED), in comparison to other canine breeds. Similar to Fuchs' endothelial corneal dystrophy (FECD), this condition is characterized by endothelial cell degeneration with secondary corneal edema. This study assessed corneal morphology using in vivo confocal microscopy (IVCM) and Fourier-domain optical coherence tomography (FD-OCT) in BTs with and without CED. Methods: The corneas of 16 BTs with CED and 15 unaffected, age-matched BTs underwent clinical evaluation and were imaged using IVCM and FD-OCT. A two-sample t-test or Mann-Whitney rank sum test were used to statistically compare parameters between groups. Data are presented as mean ?± SD or median (range). Results: Mean age did not significantly differ between affected and unaffected dogs at 10.0 ?± 2.0 and 10.6 ?± 2.4 years, respectively (P = 0.437). Females (69%) were overrepresented among the CED-affected dogs. In CED patients, IVCM demonstrated endothelial polymegathism and pleomorphism. Corneal endothelial density was significantly less (P 0.001) in dogs with CED (1026 ?± 260 cells/mm2) versus age-matched controls (2297 ?± 372 cells/mm2). Fourier-domain OCT demonstrated a significant increase (P 0.01) in central corneal and endothelium-Descemet's complex thickness in dogs with CED versus age-matched controls at 1019 (485a??1550) or 536 (464a??650) ??m and 32 (22a??56) or 25 (15a??34) ??m, respectively. Conclusions: Corneal endothelial dystrophy in BTs is a bilateral, adult-onset condition that shares many similarities with FECD. Thus, CED could serve as a spontaneous disease model to study the pathogenesis of and develop novel treatments for FECD.
机译：目的：与其他犬种相比，波士顿梗犬（BTs）的角膜内皮营养不良（CED）患病率更高。与Fuchs的内皮角膜营养不良（FECD）相似，这种疾病的特征是内皮细胞变性并伴有继发性角膜浮肿。这项研究使用体内共聚焦显微镜（IVCM）和傅立叶域光学相干断层扫描（FD-OCT）在有或没有CED的BT中评估了角膜形态。方法：对16例CED的BT和15例未受影响，年龄匹配的BT的角膜进行临床评估，并使用IVCM和FD-OCT进行成像。使用两个样本的t检验或Mann-Whitney秩和检验对两组之间的参数进行统计学比较。数据表示为平均值±SD或中值（范围）。结果：患病犬和未患病犬的平均年龄分别为10.0±2.0岁和10.6±±2.4岁，差异无统计学意义（P = 0.437）。在受CED影响的狗中，女性（69％）的人数过多。在CED患者中，IVCM表现出内皮细胞多态性和多态性。与年龄匹配的对照组（2297±±372细胞/ mm2）相比，CED犬的角膜内皮密度显着降低（P <0.001）（1026±±260细胞/ mm2）。在1019（485a ?? 1550）或536（464a ?? 650）？m处，CED犬与年龄匹配的对照组相比，傅里叶域OCT证实了中央角膜和内皮-Descemet的复杂厚度显着增加（P <0.01）和分别为32（22a≤56）或25（15a≤34）≤m。结论：BTs的角膜内皮营养不良是一种双侧成人疾病，与FECD有许多相似之处。因此，CED可以作为自发性疾病模型来研究FECD的发病机理并开发新的治疗方法。

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