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首页> 外文期刊>Investigative ophthalmology & visual science >Comparison among Standard Automated Perimetry, Microperimetry and macular Spectral Domain-OCT in glaucomatous eyes with localized visual field defects
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Comparison among Standard Automated Perimetry, Microperimetry and macular Spectral Domain-OCT in glaucomatous eyes with localized visual field defects

机译：青光眼合并局部视野缺损的标准自动视野，显微视野和黄斑光谱域-OCT的比较

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Purpose: To compare visual function evaluated by standard automatic perimetry (SAP) and microperimetry with ganglion cell inner plexiform layer (GCIPL) thickness in POAG eyes with visual field (VF) localized defects. Methods: Cross-sectional study on 23 POAG patients (23 eyes) with VF localized defects (11 males, 12 females, mean age 69.1?±9.2 years) and 23 normal subjects (23 eyes) (9 males, 14 females, mean age 66.2?±9.5 years). Complete examination, SAP (Humphrey, prog.10-2 SITA standard), Nidek MP1 microperimetry (prog. Humphrey 10-2 pattern, 4-2 strategy, Goldmann III size stimulus projected on white background), Cirrus SD-OCT imaging of macula were performed. GCIPL thickness values in the retinal areas associated with hemifield localized perimetric defects were compared with corresponding undamaged areas. Student t-test and Pearsona??s correlation coefficient (r) between the considered parameters and MD-PSD were used for statistical analysis. Results: Macular sensitivity was significantly inferior in POAGs than controls with both SAP and MP1 (p0.001). A significant difference (p0,001) in GCIPL thickness between POAG and control group was found (58.4?±8.8??m vs 78.04?±7.7??m respectively). In POAGs, GCIPL mean values, SAP 10-2 and MP1 mean sensitivity from the retinal areas associated with localized VF defects were significantly less (p0.001) than in the corresponding VF undamaged areas (GCIPL 53.9?±11.1??m vs 61.6?±10.19??m; SAP 10-2 mean sensitivity 19.7?±8.4dB vs 28.4?±3.4dB; MP1 mean sensitivity 8.2?±5.5dB vs 13.9?±3.9dB). Mean values of the same parameters in the VF undamaged retinal areas of POAGs and in the corresponding sectors of controls were significantly (p0.001) different (GCIPL 61.6?±10.19??m vs 78.7?±6.4??m; SAP 10-2 mean sensitivity 28.4?±3.4dB vs 32.2?±1.5dB; MP1 mean sensitivity 13.9?±3.9dB vs 18.7?±1.05dB). In POAGs, MD had a stronger correlation with mean total GCIPL thickness (r=0.508 p=0.013) than PSD (r=-0.185 p=0.39). SAP 10-2 and MP1 mean total sensitivity showed a good correlation with mean total GCIPL thickness (r=0.53, p=0.008 and r=0.49, p=0.016 respectively). Conclusions: MP1 and SAP findings showed a very good correlation with a corresponding OCT macular thinning, suggesting they could provide a better understanding of the amount of glaucomatous damage in the macular region.
机译：目的：比较标准自动视野检查（SAP）和显微视野检查与具有视野（VF）局部缺陷的POAG眼中神经节细胞内丛状层（GCIPL）厚度所评估的视觉功能。方法：横断面研究23例POAG VF局限性缺损患者（23眼），男性11例，女性12例，平均年龄69.1？±9.2岁; 23例正常人（23眼），男性9例，女性14例，平均年龄66.2？±9.5年）。完整检查，SAP（Humphrey，prog。10-2 SITA标准），Nidek MP1显微视野测定（promp。Humphrey 10-2型，4-2策略，Goldmann III大小刺激物投射在白色背景上），黄斑的Cirrus SD-OCT成像被执行。将与半场局限性视野缺损相关的视网膜区域中的GCIPL厚度值与相应的未损坏区域进行了比较。统计分析使用参数考虑的参数和MD-PSD之间的学生t检验和Pearsona？相关系数（r）。结果：POAG中的黄斑敏感性明显低于同时使用SAP和MP1的对照组（p <0.001）。发现POAG和对照组之间GCIPL厚度有显着差异（p <0.001）（分别为58.4？±8.8？m与78.04？±7.7？m）。在POAG中，与局部VF缺损相关的视网膜区域的GCIPL平均值，SAP 10-2和MP1的平均敏感性显着低于相应的VF未受损区域（p <0.001）（GCIPL 53.9±11.1？m vs 61.6） ？±10.19？m; SAP 10-2平均灵敏度为19.7？±8.4dB vs 28.4？±3.4dB; MP1平均灵敏度为8.2？±5.5dB vs 13.9？±3.9dB）。在POAG的VF未损坏的视网膜区域和对照的相应区域中，相同参数的平均值存在显着（p <0.001）差异（p <0.001）（GCIPL 61.6±10.19？m vs 78.7±6.4？m; SAP 10 2平均灵敏度28.4±3.4dB和32.2±1.5dB; MP1平均灵敏度13.9±3.9dB和18.7±1.05dB）。在POAG中，MD与平均总IPIPL厚度（r = 0.508 p = 0.013）的相关性比PSD（r = -0.185 p = 0.39）强。 SAP 10-2和MP1平均总灵敏度与平均总GCIPL厚度显示出良好的相关性（分别为r = 0.53，p = 0.008和r = 0.49，p = 0.016）。结论：MP1和SAP的发现与相应的OCT黄斑变薄有很好的相关性，表明它们可以更好地了解黄斑区的青光眼损伤程度。

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