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首页> 外文期刊>Investigative ophthalmology & visual science >Evaluating the Relationship Between Visual Acuity and Utilities in Patients With Diabetic Macular Edema Enrolled in Intravitreal Aflibercept Studies
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Evaluating the Relationship Between Visual Acuity and Utilities in Patients With Diabetic Macular Edema Enrolled in Intravitreal Aflibercept Studies

机译：评估玻璃体内阿柏西普研究的糖尿病性黄斑水肿患者的视力与实用性之间的关系

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Purpose: The purpose of this study was to explore the relationship between visual acuity and utility (health-related quality of life) in diabetic macular edema (DME) using intravitreal aflibercept data. Methods: The relationship between visual acuity in the best-seeing eye (BSE) and worse-seeing eye (WSE) and utility was explored using ordinary least squares (OLS) and random-effects models adjusted for different covariates (age, age2, sex, body mass index, smoking status, glycated hemoglobin, diabetes severity, comorbidities, and geographic region). Utility was measured using the EuroQoL-five dimensions questionnaire (EQ-5D) and Visual Functioning Questionnaire-Utility Index (VFQ-UI). For each model, coefficients (R2) were reported, and WSE/BSE was expressed as the ratio of coefficients (OLS models). Models were independent of treatment effects, and outcomes from all time points (up to week 100) were included where available. Results: Data from 1320 patients with DME were analyzed. In all models, the association between visual acuity (BSE WSE) was stronger with VFQ-UIa?? than EQ-5Da??derived utilities. The estimated relationship between VFQ-UI and visual acuity in the BSE and WSE was robust, even with an increasing number of covariates. WSE/BSE coefficient ratios were similar across VFQ-UI OLS models (32%) compared with EQ-5D models (41%a??48%). Actual (unadjusted) versus predicted data plots also showed a better fit with VFQ-UIa?? than EQ-5Da??derived utilities. Conclusions: These analyses show that VFQ-UI was more sensitive than EQ-5Da??derived utilities for measuring the impact of visual acuity in the BSE and WSE. Visual acuity in the BSE was a major contributor to utility, but WSE is also important though to a lesser degree as shown by the coefficient ratios. These new data will be useful for health technology assessments in DME, where utilities data are lacking.
机译：目的：本研究的目的是使用玻璃体内阿柏西普数据探讨糖尿病性黄斑水肿（DME）的视力与效用（与健康相关的生活质量）之间的关系。方法：使用普通最小二乘法（OLS）和针对不同协变量（年龄，年龄，性别，性别）调整的随机效应模型，探讨了最佳视力（BSE）和较弱视力（WSE）的视敏度与效用之间的关系，体重指数，吸烟状况，糖化血红蛋白，糖尿病严重程度，合并症和地理区域）。使用EuroQoL五维度问卷（EQ-5D）和视觉功能问卷实用性指数（VFQ-UI）来测量效用。对于每个模型，报告系数（R2），并将WSE / BSE表示为系数的比率（OLS模型）。模型与治疗效果无关，并且在可获得的情况下包括所有时间点（直至第100周）的结局。结果：分析了1320例DME患者的数据。在所有模型中，使用VFQ-UIa，视敏度（BSE> WSE）之间的关联都更强？比EQ-5Da衍生的实用程序。即使协变量数量不断增加，VFQ-UI和BSE和WSE中视敏度之间的估计关系也很可靠。在VFQ-UI OLS模型中，WSE / BSE系数比率（32％）与EQ-5D模型（41％a ?? 48％）相近。实际（未调整）与预测数据图也显示与VFQ-UIa更好地拟合？比EQ-5Da衍生的实用程序。结论：这些分析表明，VFQ-UI比EQ-5Da？实用程序对BSE和WSE中视敏度的影响更敏感。疯牛病的视敏度是效用的主要贡献者，但如系数比所示，WSE在较小程度上也很重要。这些新数据对于缺乏公用事业数据的DME中的卫生技术评估很有用。

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