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首页> 外文期刊>Investigative ophthalmology & visual science >Conjunctival Microbiome Changes Associated With Soft Contact Lens and Orthokeratology Lens Wearing
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Conjunctival Microbiome Changes Associated With Soft Contact Lens and Orthokeratology Lens Wearing

机译：与软性隐形眼镜和角膜塑形镜配戴相关的结膜微生物组变化

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Purpose: Usage of different types of contact lenses is associated with increased risk of sight-threatening complications. Changes in the ocular microbiome caused by contact lens wear are suggested to affect infection development in those individuals. To address this question, this study compares conjunctival microbial communities in contact lens wearers with those in noncontact lens wearers. Methods: Paired-end sequencing of the V3 region of the 16S rRNA gene was used to characterize the bacterial communities on the conjunctival surfaces of contact lens wearers and nonwearers. Results: No differences in microbial diversity were detected between contact lens wearers and nonwearers. Nevertheless, some slight microbe variability was evident between these two different groups. Bacillus, Tatumella and Lactobacillus abundance was less in orthokeratology lens (OKL) wearers than in nonwearers. In soft contact lenses (SCL) wearers, Delftia abundance decreased whereas Elizabethkingia levels increased. The difference in the SCL and nonwearer group was smaller than that in the OKL group. Variations in the conjunctival taxonomic composition between SCL wearers were larger than those in other groups. Sex differences in the conjunctival microbiota makeup were only evident among nonwearers. Conclusions: Even though there were slight percentage changes between contact lens wearers and nonwearers in some microbes, there were no differences in their diversity. On the other hand, contact lens usage might cause relative abundance of some taxa to change. Our results will help assess whether or not conjunctival microbiome changes caused by contact lens wear affect infection risk.
机译：目的：使用不同类型的隐形眼镜会增加威胁视力的并发症的风险。建议由隐形眼镜配戴引起的眼部微生物组变化影响这些个体的感染发展。为了解决这个问题，本研究比较了隐形眼镜配戴者和非隐形眼镜配戴者的结膜微生物群落。方法：采用16S rRNA基因V3区的双末端测序技术，对隐形眼镜佩戴者和非佩戴者的结膜表面细菌群落进行鉴定。结果：隐形眼镜佩戴者和非佩戴者之间没有发现微生物多样性的差异。然而，在这两个不同的组之间，微生物存在一些轻微的变异性。角膜塑形镜（OKL）佩戴者中的芽孢杆菌，塔氏杆菌和乳杆菌的丰度低于不佩戴者。在软性隐形眼镜（SCL）佩戴者中，代夫特氏丰度降低，而伊丽莎白女王的水平增加。 SCL组和非佩戴者组的差异小于OKL组。 SCL佩戴者之间结膜分类学组成的差异大于其他组。结膜微生物群组成中的性别差异仅在不佩戴者中明显。结论：即使在某些微生物中，隐形眼镜佩戴者和非佩戴者之间的百分比变化很小，但它们的多样性没有差异。另一方面，隐形眼镜的使用可能会导致某些分类单元的相对丰度发生变化。我们的结果将有助于评估由隐形眼镜佩戴引起的结膜微生物组变化是否影响感染风险。

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