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Molecular and Epidemiologic Analysis of Dengue Virus Isolates from Somalia

机译:索马里登革病毒分离株的分子和流行病学分析

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Nucleotide sequence analysis was performed on 14 dengue virus isolates (13 dengue-2 viruses and 1 dengue-3 virus) recovered from febrile soldiers in Somalia in 1993. The dengue-2 viruses were most closely related to dengue-2 virus recovered in Somalia in 1984. However, differences in nucleotide sequence (0.35% to 1.35%) were evident among the 1993 isolates. These differences were closely associated with the geographic location of the infection as well as with different times of infection at the same location. Genetic difference between strains was not associated with differences in clinical features. Molecular analysis of dengue viruses is a useful adjunct to epidemiologic investigation of their distribution over distance and time.
机译:对1993年从索马里的发热士兵中回收的14个登革热病毒分离株(13个登革热2病毒和1个登革热3病毒)进行了核苷酸序列分析。登革热2病毒与索马里2002年在索马里回收的登革热2病毒关系最密切。 1984年。但是,在1993年分离株之间,核苷酸序列差异明显(0.35%至1.35%)。这些差异与感染的地理位置以及同一位置的不同感染时间密切相关。菌株之间的遗传差异与临床特征的差异无关。登革热病毒的分子分析是流行病学调查其随时间和距离分布的有用辅助工具。

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