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Leishmaniasis among Gold Miners, French Guiana

机译:法属圭亚那金矿工中的利什曼病

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To the Editor: In 2004, theCayenne General Hospital and publichealth centers recorded 348 new casesof cutaneous leishmaniasis (CL) inFrench Guiana (1). A case of CL wasconsidered confirmed if cutaneouslesions were present for >2 weeks; thepatient had a compatible epidemio-logic history; and microscopic exami-nation of dermal scrapings, parasitecultivation, or both showed positiveresults for Leishmania. According tothe population estimate given by theFrench National Institute for Statisticsand Economical Studies (INSEE,Cayenne), the incidence of CL in2004 was 0.2%–0.4% and has beenrelatively stable since 1979 (2,3).However, when the annual number ofcases per village were examined, newCL cases were heterogeneously dis-tributed. Saint Elie, a gold-mining vil-lage in the inland neotropical forest,had an apparent incidence rate of25.9% in 2004 and 28.9% in 2005(Figure); risk for infection in this vil-lage was, on average, 65×higher thananywhere else in French Guiana. Wetested samples from 12 random CLpatients with a Leishmania-specificpolymerase chain reaction–restrictionfragment length polymorphism testthat targeted the internal transcribedspacer 1 of ribosomal RNA geneswith primers SSU-12103-D (5′-GGGAATATCCTCAGCACGT-3′)and 5.8S-13333-R (5′-CGACACT-GAGAATATGGCATG-3′) (4). Allthese patients were infected withLeishmania guyanensis
机译:致编辑:2004年,卡宴综合医院和公共卫生中心在法属圭亚那记录了348例新的皮肤利什曼病(CL)病例(1)。考虑到CL病例,确认皮损是否存在> 2周;该患者具有适当的流行病学史;真皮刮片,寄生虫培养或两者的显微镜检查均显示利什曼原虫呈阳性结果。根据法国国家统计和经济研究所(INSEE,Cayenne)的人口估计,CL的发病率在2004年为0.2%-0.4%,自1979年以来一直相对稳定(2,3)。对村庄进行了检查,新分布的CL病例是异类分布的。内陆新热带森林中的金矿村Saint Elie,其表观发病率在2004年为25.9%,在2005年为28.9%(图)。该村的感染风险平均比法属圭亚那的其他地区高65倍。我们用利什曼原虫特异性聚合酶链反应-限制性片段长度多态性测试对12名随机性CL患者的样本进行了测试,这些样本使用引物SSU-12103-D(5'-GGGAATATCCTCAGCACGT-3')和5.8S-13333-R(针对核糖体RNA基因的内部转录间隔子1) 5′-CGACACT-GAGAATATGGCATG-3′)(4)。所有这些患者均感染了古曼利什曼原虫

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