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首页> 外文期刊>Emerging Infectious Diseases >Human Hendra Virus Encephalitis Associated with Equine Outbreak, Australia, 2008
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Human Hendra Virus Encephalitis Associated with Equine Outbreak, Australia, 2008

机译：2008年澳大利亚与马匹爆发相关的人类亨德拉病毒脑炎

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A recent Hendra virus outbreak at a veterinary clinic in Brisbane, Queensland, Australia, involved 5 equine and 2 human infections. In contrast to previous outbreaks, in-fected horses had predominantly encephalitic, rather than respiratory, signs. After an incubation period of 9–16 days, in. uenza-like illnesses developed in the 2 persons before progressing to encephalitis; 1 died. Both patients were giv-en ribavirin. Basal serum and cerebrospinal . uid levels were 10–13 mg/L after intravenous administration and 6 mg/L af-ter oral administration (isolate 90% inhibitory concentration 64 mg/L). Both patients were exposed to infected horses, 1 during the late incubation period in a horse. The attack rate for veterinary clinic staff exposed to infected horses was 10%. An isolate from this outbreak showed genetic hetero-geneity with isolates from a concurrent, but geographically remote, outbreak and from previous outbreaks. Emergence of Hendra virus is a serious medical, veterinary, and public health challenge
机译：最近在澳大利亚昆士兰州布里斯班的一家兽医诊所爆发的亨德拉病毒爆发，涉及5匹马和2例人类感染。与以前的疫情相比，受感染的马主要是脑病，而不是呼吸道病。潜伏了9-16天后，在2人中出现了类流感样疾病，然后发展为脑炎。 1人死亡。两名患者均为吉夫-恩利巴韦林。基础血清和脑脊液。静脉内给药后的uid水平为10-13 mg / L，口服后为6 mg / L（90％的抑制浓度为64 mg / L）。两名患者均在马的潜伏后期暴露于受感染的马中，1。接触感染马匹的兽医诊所工作人员的袭击率为10％。这次暴发的分离株显示出遗传异质性，同时发生但在地理上较远的暴发以及以前暴发的分离株。亨德拉病毒的出现是严重的医学，兽医和公共卫生挑战

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